Effect of inorganic polyphosphate in periodontitis in the elderly

Gerodontology
M YamaokaK Furusawa

Abstract

Inorganic polyphosphate exists as chains of phosphate molecules and is distributed in osteoblasts, and regulates osteoblastic cell differentiation and bone matrix calcification. The purpose of this study was to clarify the effects of inorganic polyphosphate on periodontitis. Subgingival local irrigation with inorganic polyphosphate was studied in a randomised double-blind study of 33 patients with periodontitis. Scaling and root planing were performed 1 week after the initial examination. No significant differences between the inorganic polyphosphate group and control were detected in each item except IL-1beta. Patients in whom both the bleeding on probing and gingival index at 1 week had improved were significantly older in the inorganic polyphosphate group than in the control group (p < 0.05). Bone regeneration was seen in one case of the inorganic polyphosphate group. Inorganic polyphosphate was useful in the treatment of periodontitis in the elderly, indicating a probable effect of anti-ageing, with similar bone regenerations occurring in both groups.

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Citations

Feb 11, 2010·Journal of Bone and Mineral Metabolism·Daiki MorimotoHideki Yoshikawa
Oct 23, 2012·Biochemical and Biophysical Research Communications·Ningyuan SunQuan Yuan
Dec 11, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Brian L FosterMartha J Somerman
Aug 28, 2019·Journal of Applied Biomaterials & Functional Materials·Iain GibsonMark Filiaggi
May 29, 2010·Environmental Science & Technology·Julia M Diaz, Ellery D Ingall
May 18, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kanchi Baijal, Michael Downey

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