Effect of inositol stereoisomers at different dosages in gestational diabetes: an open-label, parallel, randomized controlled trial

Acta Diabetologica
Federica FraticelliEster Vitacolonna

Abstract

Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27.6 mg myo/D-chiro-inositol plus 400 mcg folic acid (MI plus DCI treatment). The homeostasis model assessment of insulin resistance (HOMA-IR) was measured at the diagnosis of GDM and after 8 weeks of treatment. Secondary outcomes, obstetric outcomes and any maternal or fetal complication at delivery were also collected. Eighty GDM women were assigned to one of the four arms of study (20 per arm). A significant delta decrease in HOMA-IR index was found in subjects of MI group without insulin therapy compared to control group (p < 0.001). A lower variation in average weight gain (at delivery vs pre-pregnancy and OGTT period) was detected in MI group vs control group (p = 0.001 and p = 0.019, respectively). Moreover, women exposed to M...Continue Reading

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Citations

Sep 24, 2020·Expert Opinion on Drug Metabolism & Toxicology·Fabio FacchinettiUNKNOWN Experts Group on Inositol in Basic and Clinical Research
Mar 20, 2019·Diabetes/metabolism Research and Reviews·Gloria FormosoAgostino Consoli
Aug 23, 2020·Biomedicines·Antonio J López-GamberoFernando Rodríguez de Fonseca
Dec 8, 2020·Critical Reviews in Food Science and Nutrition·Oliver C WatkinsShiao-Yng Chan
Jan 7, 2020·Journal of Neonatal-perinatal Medicine·G ZitoS Garzon
Mar 16, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Vidushi KulshresthaNeerja Bhatla
Jun 26, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mariano BizzarriAntonio Simone Laganà

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