PMID: 6987116Apr 1, 1980Paper

Effect of insulin, glucose, and 2-deoxy-glucose infusion into the third cerebral ventricle of conscious dogs on plasma insulin, glucose, and free fatty acids

Diabetes
G J Taborsky, R N Bergman

Abstract

Previous studies have demonstrated that exogenous insulin, injected into central cerebrospinal fluid cavities of dogs, stimulates the release of endogenous insulin from the pancreas. To determine whether this response was elicited by (1) insulin per se, (2) an effect of insulin on glucose transport, or (3) glucopenia in the cerebrospinal fluid, we measured plasma insulin, glucose, and free fatty acids during the infusion of insulin, glucose, and 2-deoxy-glucose (2DG), individually or in combination, into the third cerebral ventricle of conscious dogs. As expected, the third ventricular infusion of insulin alone elicited a small, but significant, rise of plasma insulin. Surprisingly, infusion of insulin with glucose produced a smaller increase of plasma insulin (P less than 0.05) and the infusion of insulin with 2DG produced a much larger increase of plasma insulin (P less than 0.05) than did the third ventricular infusion of insulin alone. The third ventricular infusion of either glucose alone or 2DG alone had no effect on the plasma levels of insulin. These data suggest that administration of insulin into the cerebral ventricles stimulates pancreatic insulin secretion but not by accelerating the transport of glucose into a che...Continue Reading

Citations

Jan 1, 1986·Physiology & Behavior·C R Plata-SalamánN Shimizu
Oct 1, 1992·Physiology & Behavior·P Marfaing-JallatL Penicaud
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J C Mathers, M E Daly
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·A B SteffensJ W Scheurink
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Apr 5, 2011·Journal of Theoretical Biology·Zimei WuStephen Chang
Jun 1, 1983·Metabolism: Clinical and Experimental·E W KraegenL V Campbell

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.