Effect of insulin-like growth factor 1 gene on growth traits of Kejobong goat and its growth analysis

Veterinary World
Dela Ayu LestariEdy Kurnianto

Abstract

This study aimed to identify the effect of the insulin-like growth factor 1 (IGF1) gene on growth, to uncover the genetic marker at the IGF1 gene, and to predict growth performance by analyzing growth models of Kejobong goats based on their genotype. DNA and records of body weight (BW) and body measurements (BM) of Kejobong goats were collected, the IGF1 gene was amplified from the DNA template by polymerase chain reaction (PCR); the PCR products were then sequenced to determine single nucleotide polymorphisms (SNP). Linear mixed model (LMM) was used to analyze the association between SNP and growth traits. Four non-linear growth models were analyzed using non-LMM to describe the growth model and to compare the growth within genotypes. An SNP at intron 4 (g5752G→C) genotyped into GG and CC was significantly associated with BW and BM. Goats of genotype GG had a significantly higher BW and BM (p<0.05) than those of genotype CC. Growth analysis showed that the von Bertalanffy model was the most fit for describing BW, the Brody model for chest width and hip height, the Gompertz and Logistic models for heart girth, and the von Bertalanffy and Gompertz models for hip width. An SNP at intron 4 of the IGF1 gene was associated with the ...Continue Reading

References

Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Dec 24, 2015·Animal : an International Journal of Animal Bioscience·T M LupiJ V Delgado
Jan 7, 2016·Journal of Translational Medicine·G A AguirreI Castilla-Cortazar
Oct 19, 2017·International Journal of Molecular Sciences·Stefania OrrùEsther Imperlini

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Methods Mentioned

BETA
blood

Software Mentioned

NLMM
SAS

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