Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

Neuroreport
Madhavan NampoothiriChamallamudi Mallikarjuna Rao

Abstract

Latest reports suggest the involvement of insulin in modulating memory. A few published in-vitro studies favor the antidementia effect of insulin. Thus, the present study aimed to evaluate the prophylactic role of insulin and its combination with glucose and its possible mechanism(s) in an aluminum chloride (AlCl3)-induced cognitive dysfunction model in rodents, with a special focus on memory centers namely, the hippocampus and the frontal cortex. Male Wistar rats were exposed to AlCl3 (175 mg/kg orally) for 60 days. Insulin (0.5 IU/kg), Insulin (0.5 IU/kg) in combination with glucose (200 mg/kg), and rivastigmine (1 mg/kg) were administered intraperitoneally 45 min before the administration of AlCl3 for 60 days. Spatial memory was assessed using the Morris water-maze test. After 60 days of treatment, animals were killed, and the hippocampus and frontal cortex were collected and analyzed for acetylcholinesterase activity and antioxidant enzyme level. Blood glucose levels were also analyzed. Treatment with the standard drug, rivastigmine (1 mg/kg), produced a significant reduction in escape latency and increased the time spent in the target quadrant compared with the AlCl3-treated group. Insulin and its combination with glucose ...Continue Reading

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·C Struys-PonsarP van den Bosch de Aguilar
Aug 28, 1998·Journal of Neural Transmission·L FrölichP Riederer
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Feb 26, 2004·Lancet Neurology·Suzanne Craft, G Stennis Watson
Jun 20, 2006·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ved Chauhan, Abha Chauhan
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pascale N LacorWilliam L Klein
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Mar 29, 2011·European Journal of Pharmacology·Raafat A Abdel-AalBotros B Kostandy
Sep 8, 2012·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Nov 19, 2013·The Journal of Pharmacy and Pharmacology·Kafeel A KhanJayesh Mudgal
Jul 16, 2014·Behavioural Neurology·Madhavan NampoothiriMallikarjuna Rao Chamallamudi
Oct 30, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Nitesh KumarAanesha Ghosh
Mar 25, 2015·Behavioural Neurology·Madhavan NampoothiriMallikarjuna Rao Chamallamudi

❮ Previous
Next ❯

Citations

May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Firas H BazzariHanan S El-Abhar
Aug 29, 2019·Journal of Histotechnology·Hesham N Mustafa
Mar 14, 2020·Mini Reviews in Medicinal Chemistry·Bellamkonda BosebabuNitesh Kumar
Sep 3, 2020·Neuropeptides·Indrani GhoshMadhavan Nampoothiri
Nov 11, 2021·Journal of Biochemical and Molecular Toxicology·Komal JabeenMuhammad Sajid Hamid Akash

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.