1. Decreased beta-adrenergic responses have been reported in both gastro-intestinal tract and atrium of experimentally-induced diabetic rats. The present study was undertaken to investigate in vitro effects of insulin on decreased beta-adrenergic responses of the duodenum and atrium from streptozotocin-diabetic rats. 2. Insulin incubation (16.67 micrograms/ml) in bathing medium for 5 hr enhanced the decreased beta-adrenergic responses in the diabetic rat duodenum, but not those in the diabetic atrium. Incubation of bovine insulin with anti-bovine insulin antibody in the test-tube inhibited the improving effect of insulin on the decreased beta-adrenergic responses of diabetic rat duodenum. 3. In vitro treatment with the same dose of bovine insulin in bathing medium caused a decrease in the beta-adrenergic responses of the atria from both non-diabetic and diabetic rats. Anti-bovine insulin antibody also abolished the inhibitory effect of insulin on the rat atria. 4. These results strongly suggest that the experimental diabetes affects beta-adrenergic responsiveness of the rat gastro-intestinal tract through a different mechanism from that of the rat myocardium.
Prevention of streptozotocin-induced alterations in the rat heart by 3-O-methyl glucose and insulin treatments
Effect of L-carnitine treatment on lipid metabolism and cardiac performance in chronically diabetic rats
Decreased gastro-intestinal responses to certain agonists in streptozotocin- and alloxan-diabetic rats in vitro
Decreased gastro-intestinal responses to salbutamol and serotonin in streptozotocin-induced diabetes: improving effect of insulin in vivo and in vitro
Altered responses to calcium and trifluoperazine in K+-depolarized duodenum from alloxan diabetic rats
The effect of chronic alloxan- and streptozotocin-induced diabetes on isolated rat heart performance
Decreased beta-adrenergic receptors in rat heart in streptozotocin-induced diabetes: role of thyroid hormones
Incorporation of C14-amino acids into protein of isolated diaphragms: an effect of insulin independent of glucose entry
The effects of glyburide and insulin on the decreased beta-adrenergic responsiveness of the gastrointestinal tract in rats with non-insulin-dependent diabetes
Altered alpha-adrenergic responses of vas deferens to noradrenaline and tyramine from rats with short- and long-term alloxan diabetes
Increased alpha 1-adrenergic responsiveness of alloxan diabetic rat atria: effects of insulin therapy and thyroidectomy
Increased responses to adenosine in isolated left atria from streptozotocin-diabetic rats: evidence for the involvement of hypothyroidism
Adrenergic Receptors: Trafficking
Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.