Effect of intensive versus standard blood pressure control on depression and health-related quality of life in type 2 diabetes: the ACCORD trial.

Diabetes Care
Patrick J O'ConnorMark D Sullivan

Abstract

We tested the hypothesis that intensive (systolic blood pressure [SBP] <120 mmHg) rather than standard (SBP 130-139 mmHg) blood pressure (BP) control improves health-related quality of life (HRQL) in those with type 2 diabetes. Subjects were 1,028 ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial HRQL substudy participants who completed baseline and one or more 12-, 36-, or 48-month HRQL evaluations. Multivariable linear regression assessed impact of BP treatment assignment on change in HRQL. Over 4.0 years of follow-up, no significant differences occurred in five of six HRQL measures. Those assigned to intensive (vs. standard) BP control had statistically significant worsening of the Medical Outcomes Study 36-item short-form health survey (SF36) physical component scores (-0.8 vs. -0.2; P = 0.02), but magnitude of change was not clinically significant. Findings persisted across all prespecified subgroups. Intensive BP control in the ACCORD trial did not have a clinically significant impact, either positive or negative, on depression or patient-reported HRQL.

References

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Citations

Apr 20, 2014·Current Diabetes Reports·Richard I G HoltSherita Hill Golden
Apr 15, 2014·Journal of the American Society of Hypertension : JASH·Michael J BurlaPhillip D Levy
Mar 23, 2018·Nature Reviews. Disease Primers·Suzanne OparilPaul K Whelton
Jun 15, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ruohua YanUNKNOWN CHIEF Research Group
Feb 6, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kathryn Evans Kreider
Aug 29, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Benjamin Emmert-AronsonSteven Chen
Aug 24, 2017·The New England Journal of Medicine·Dan R BerlowitzUNKNOWN SPRINT Research Group
Mar 7, 2020·The Lancet. Diabetes & Endocrinology·Thomas T van SlotenCoen D A Stehouwer

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