Effect of interferon α2a in cystoid macular edema due to intraocular infection

European Journal of Ophthalmology
Zhuyun QianPhuc LeHoang

Abstract

Cystoid macular edema (CME) is a severe complication and a major cause of visual loss in patients with intraocular infection. In this type of CME, therapeutic strategies remain controversial. We aimed to investigate the efficacy and tolerability of interferon (IFN)-α2a in cystoid macular edema caused by intraocular infection. In this retrospective, noncomparative, interventional case series, 5 patients (6 eyes) who were diagnosed with intraocular infection with chronic CME were included. Interferon-α2a (3 million units 3 times a week) was administered subcutaneously. Clinical observations were recorded before and after treatment. The average duration of CME before treatment with IFN-α was 26 months. According to the preset criteria, IFN-α2a therapy was shown to be effective in 2 patients (3 eyes), effective dose-dependent in 2 patients, and partly effective in 1 patient, and was well-tolerated in 4 patients. The most common side effect was flu-like symptoms. Interferon α-2a may be an effective alternative treatment for CME due to intraocular infection that is resistant to other treatment. Studies with larger sample sizes are required to confirm this conclusion.

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Citations

Apr 6, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Natalia LewczukJoanna Bogusławska
Jun 5, 2019·Ocular Immunology and Inflammation·Hilal Eser-Ozturk, Yuksel Sullu
Feb 23, 2018·Ocular Immunology and Inflammation·Alessandro InvernizziLuca Cimino
Dec 11, 2019·Ocular Immunology and Inflammation·Chloé CouretMichel Weber
Feb 15, 2020·Ocular Immunology and Inflammation·Aleksandra RadosavljevicManfred Zierhut
Apr 18, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Merih OrayIlknur Tugal-Tutkun
Jul 31, 2021·World Journal of Diabetes·Bing-Yan LiYe-Di Zhou
Aug 5, 2021·Ocular Immunology and Inflammation·Nihan Aksu-CeylanIlknur Tugal-Tutkun

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