PMID: 2493541Feb 1, 1989Paper

Effect of interferon alpha, gamma, and tumor necrosis factor alpha on the HLA-A, B, C expression of cell lines derived from human liver

Liver
K YoshiokaA Fuji

Abstract

Our study was undertaken to determine whether human recombinant interferon alpha(rIFN alpha), gamma(rIFN gamma), and tumor necrosis factor alpha(rTNF alpha) exert an effect on the HLA-A, B, C expression of human liver cell lines. The HLA-A, B, C expression was assayed by immunoperoxidase staining and enzyme-linked immunosorbent assay. rIFN alpha and gamma enhanced the HLA-A, B, C expression of the three cell lines tested, Chang cells, SK-Hep-1, and PLC/PRF/5. The activity of rIFN gamma proved more than 8000 times more potent than that of rIFN alpha in Chang cells, 30 times in SK-Hep-1, and 20 times in PLC/PRF/5, respectively. rTNF alpha also enhanced the HLA-A, B, C expression of the three cell lines. The enhancement of HLA-A, B, C expression by rIFN alpha and gamma reached a peak on day 3, and that by rTNF alpha on day 5. These findings suggest that IFN alpha, IFN gamma, and TNF alpha may play similar roles in enhancement of HLA-A, B, C expression of hepatocytes in hepatitis and hepatoma cells.

References

May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PignatelliH C Thomas
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T CollinsJ S Pober
Aug 7, 1986·Nature·H Festenstein, F Garrido
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T Y BashamT C Merigan
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L MontanoH C Thomas
Nov 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·R S M CHANG

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