PMID: 9167180Apr 1, 1997Paper

Effect of interferon-alpha on the expression of tumour necrosis factor-alpha by metastatic malignant melanoma in vivo

Melanoma Research
A HåkanssonL Håkansson

Abstract

To our knowledge modulation of the expression of tumour necrosis factor-alpha (TNF-alpha) in malignant melanoma metastases in vivo has not been reported. The expression of TNF-alpha by malignant melanoma cells was studied immunohistochemically using an anti-TNF-alpha antibody. The specificity of the staining reaction was demonstrated by absorption of the TNF-alpha antibody with human recombinant TNF-alpha, which inhibited the staining reaction. The TNF-alpha expression was also verified by in situ hybridization for mRNA. Metastases from 37 patients were studied, 21 of whom were treated with IFN-alpha. All 16 metastases from untreated patients were positive for TNF-alpha. Based on the average staining intensity of the melanoma cells for TNF-alpha, the metastases were classified into two groups. The expression of TNF-alpha varied considerably between metastases from different patients and also within the same metastasis. Melanoma cells in areas with low cellularity and large numbers of infiltrating inflammatory cells were generally weakly stained. This is in good agreement with a low staining score for TNF-alpha in metastases showing marked histopathological regression. Seven out of 13 patients with a low staining score for TNF-a...Continue Reading

Citations

Mar 25, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A HåkanssonL Håkansson
Nov 20, 2012·The American Journal of Pathology·Kathleen SchubertAnja Saalbach
Feb 12, 2014·Dermatology Research and Practice·Aimen Ismail, Nabiha Yusuf
Sep 19, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fabio Romerio, Davide Zella
Mar 10, 2017·Expert Opinion on Biological Therapy·Martina SanlorenzoDario Sangiolo
Apr 2, 2003·Cancer Immunology, Immunotherapy : CII·Annika HåkanssonLeif Håkansson

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