Effect of interferon-alpha therapy on bone marrow fibrosis in chronic myelogenous leukemia

Leukemia
M WilhelmH Kantarjian

Abstract

The aim of this study was to investigate the influence of interferon-alpha (IFN-alpha) on bone marrow fibrosis associated with chronic myelogenous leukemia (CML). Eighty-two bone marrow biopsies from 41 patients in chronic phase CML were stained with Snook's reticulin stain for argyrophilic fibers. Grading of reticulin fibrosis (scale of 1 to 4) was according to the quantity and pattern of distribution of reticulin. The interval between biopsies was a median of 25 months (range 12 to 40 months). Patients had been treated with IFN-alpha for at least 12 months, were still on IFN-alpha therapy during the study, and had achieved at least a complete hematological response. Before the start of IFN-alpha therapy, reticulin fibrosis was grade 1-2 in 23 patients (56%) and grade 3-4 in 18 (44%). During IFN-alpha therapy, reticulin fibrosis in bone marrow did not worsen or was reduced in 33 patients (80%) and increased by one grade in eight patients (20%). Only five patients (12%) with limited fibrosis (grade 1-2) before start of IFN-alpha therapy showed an increase towards significant fibrosis (grade 3-4), while eight of the 18 patients (44%) with grade 3-4 fibrosis achieved a decrease of fiber content in bone marrow. In summary, IFN-alp...Continue Reading

Citations

Apr 11, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Brady L Stein, Ramon V Tiu
Jul 10, 1999·Current Opinion in Hematology·U R Osarogiagbon, P B McGlave
Jun 26, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Jürgen Thiele, Hans M Kvasnicka
Jun 20, 2006·Best Practice & Research. Clinical Haematology·J ThieleJ Vardiman
Dec 30, 1999·Nature Genetics·C S HuettnerD G Tenen
Jul 15, 2017·World Journal of Cardiology·Kazuaki NishioHideaki Tachibana
Sep 5, 2006·The Oncologist·Cecilia Arana-YiSrdan Verstovsek
Jul 31, 1999·Annals of Internal Medicine·S FaderlH M Kantarjian

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