PMID: 11315506Apr 24, 2001Paper

Effect of interferon-gamma on the susceptibility to Fas (CD95/APO-1)-mediated cell death in human hepatoma cells

Cancer Immunology, Immunotherapy : CII
E C ShinS J Kim

Abstract

Many tumors, including hepatocellular carcinomas (HCCs), resist Fas-mediated cell death, which is one of the effector mechanisms in the host's anti-tumor response; however, this resistance can be abolished by interferon-gamma (IFN-gamma). IFN-gamma may sensitize Fas-mediated cell death in several ways, but the exact mechanism in HCCs is uncertain. In this study, we thoroughly investigated the effect of IFN-gamma on the susceptibility of one human normal liver cell line and 12 HCC cell lines to Fas-mediated cell death. We also investigated the effect of IFN-gamma on the expression of various apoptosis-related genes such as the Fas/TNF-related genes, the bcl-2 family, and the caspase family of genes. Although most cell lines showed considerable constitutive expression of Fas, all tested cell lines resisted Fas-mediated cell death without IFN-gamma. When cells were pretreated with IFN-gamma, only three cell lines were made significantly susceptible to Fas-mediated cell death (SNU-354, SNU-387 and SNU-423); the other 10 cell lines were not affected. IFN-gamma increased the mRNA expression of Fas, TRAIL and caspase-1, and surface Fas was also increased. The strongly sensitized cell lines (SNU-354, SNU-387 and SNU-423) showed a parti...Continue Reading

Citations

Jul 16, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael J Clemens
Oct 30, 2004·European Journal of Biochemistry·Sang-Youel ParkDai-Wu Seol
Feb 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ja-Lok Ku, Jae-Gahb Park
Feb 16, 2002·Biochemical and Biophysical Research Communications·Sang-Youel ParkDai-Wu Seol
Apr 14, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·A LegrandG Feldmann
Oct 30, 2014·Cancer Immunology, Immunotherapy : CII·Xiaofeng WangMarianna Kulka
Nov 15, 2013·Clinical & Experimental Ophthalmology·Xiao Yang WangPaul R Healey
Feb 4, 2009·Journal of Cardiovascular Pharmacology·Victoria E A Stoneman, Martin R Bennett
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A TaylorM Bennett
May 17, 2007·International Journal of Experimental Pathology·C T McCulloughD J Harrison

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