PMID: 6171991Jun 1, 1981Paper

Effect of interferon preparations on the uptake of non-opsonized Escherichia coli by mouse peritoneal macrophages

Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
H Rollag, M Degre

Abstract

Uptake of non-opsonized Escherichia coli by mouse peritoneal macrophages (MPM) is influenced by pre-treatment of MPM with homologous interferon preparations. Incubation of MPM with 10(2)-10(3) units of interferon per ml for 18 hours resulted in a 30-70 per cent increase in the phagocytosis rate as well as maximal phagocytic capacity. This effect was time dependent. At least seven hours of interferon pre-treatment and a phagocytosis period of 90 minutes were necessary for a statistically significant increase of the phagocytosis. Treatment of MPM with high concentrations of interferon (i.e. more than 10(4) units per ml) had a depressive effect on the phagocytosis. Both the enhancing and the depressive effects were characterized by the standard physico-chemical properties of interferons. Both effects were species specific. The phagocytosis enhancing effect was neutralized by anit-interferon serum.

References

May 1, 1978·Infection and Immunity·O StrannegårdH Persson
Apr 1, 1976·Infection and Immunity·R M Donahoe, K Y Huang
Nov 1, 1971·Infection and Immunity·K Y HuangH R Dressler
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·W Braun, H B Levy
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Feb 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·V I OYAMA, H EAGLE
Mar 1, 1970·Infection and Immunity·F F Pindak

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Citations

Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·O R Burrone, C Milstein
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M DegréE Kjeldsberg

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