Effect of interferon therapy on human papillomavirus copy number in patients with Condyloma acuminatum

The American Journal of the Medical Sciences
I AranyS K Tyring

Abstract

Interferons exert antiviral, antiproliferative, and immunomodulatory effects on target cells. The effectiveness of interferon treatment can be followed by measuring parameters involved in interferon action. The clinical effectiveness of interferons has been proved in the human papillomavirus (HPV)-associated disease condyloma acuminatum. Because one of the most important goals in the treatment of this condition is the elimination of recurrences, it was asked whether clinically effective interferon therapy was associated with elimination of HPV DNA. The authors used a polymerase chain reaction-based method to detect the HPV from minute amounts of clinical biopsies. Human papillomavirus-transformed cell lines or cloned HPV genomes served as different copy number controls. The intensity ratio of L1 HPV and the human beta-globin (which served as an internal control) fragments was determined and used for estimation of HPV copy number in different biopsies. A direct effect of interferon treatment on HPV viral genome copies was observed in a group of responder patients, but not in the clinically resistant group. With these data, a correlation was found between virologic data and clinical findings. This method also can be used in other...Continue Reading

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Citations

Jun 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I Arany, S K Tyring
Jul 5, 2005·Expert Opinion on Investigational Drugs·H B SladeR L Miller
Oct 27, 2009·Archives of Medical Research·Lutz Gissmann, Karen Nieto
Mar 10, 2001·Clinical and Diagnostic Laboratory Immunology·M ScottA B Moscicki

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