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Effect of interleukin-1 beta on growth hormone gene expression and its possible molecular mechanism in rat MtT/S somatotroph cells

Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih

Feb 3, 2009

Feng-Ying GongYi-Fan Shi

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PubMed

Abstract

To elucidate the effect of interleukin-1 beta (IL-1 beta) on human growth hormone (hGH) gene expression in a rat somatotropic pituitary cell line MtT/S. Stably transfected MtT/S cells were firstly established by transfecting 484-Luc1 plasmid which contained hGH gene promoter -484 to +30...read more

Mentioned in this Paper

Biochemical Pathway
Growth Hormone Activity
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 14
Interleukin-1
Transcription Factor Pit-2
Somatotrophs
Gene Deletion Abnormality
Transduction
Promoter
Paper Details
References
  • References22
  • Citations2
123
  • References22
  • Citations2
1

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Effect of interleukin-1 beta on growth hormone gene expression and its possible molecular mechanism in rat MtT/S somatotroph cells

Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih

Feb 3, 2009

Feng-Ying GongYi-Fan Shi

PMID: 19180878

DOI: 10.1016/s1001-9294(09)60038-9

Abstract

To elucidate the effect of interleukin-1 beta (IL-1 beta) on human growth hormone (hGH) gene expression in a rat somatotropic pituitary cell line MtT/S. Stably transfected MtT/S cells were firstly established by transfecting 484-Luc1 plasmid which contained hGH gene promoter -484 to +30...read more

Mentioned in this Paper

Biochemical Pathway
Growth Hormone Activity
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 14
Interleukin-1
Transcription Factor Pit-2
Somatotrophs
Gene Deletion Abnormality
Transduction
Promoter

Feeds With Similar Papers

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

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Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih

Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth hormone gene expression in rat MtT/S somatotroph cells

Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa ChihAugust 9, 2008
Feng-Ying GongYi-Fan Shi
Paper Details
References
  • References22
  • Citations2
123
  • References22
  • Citations2
1

Download from

Publisher
PubMed
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