Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells

British Journal of Pharmacology
L Pang, A J Knox

Abstract

1. Increased levels of several pro-inflammatory cytokines including interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF alpha) have been found in bronchoalveolar lavage fluid from symptomatic asthmatic patients. IL-1 beta, TNF alpha and interferon-gamma (IFN gamma) are known to stimulate a number of cells to produce inflammatory mediators such as prostaglandins. Although airway smooth muscle (ASM) is known to be a rich source of prostaglandins, the regulation of cyclo-oxygenase (COX) isoforms and prostanoid production by proinflammatory cytokines have not been studied in human airway smooth muscle. 2. We studied the effects of IL-1 beta, TNF alpha and IFN gamma on the induction of two isoforms of cyclo-oxygenase and its relation to prostaglandin E2 (PGE2) release and COX activity (reflected by PGE2 synthesis from exogenous arachidonic acid) in human cultured airway smooth muscle cells. 3. IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products. This stimulation was accompanied by a corresponding increase in CO...Continue Reading

References

Feb 28, 1979·Cell and Tissue Research·L RifasS Seifter
May 1, 1992·The Journal of Allergy and Clinical Immunology·D H BroideS I Wasserman
Oct 1, 1992·British Journal of Pharmacology·I P HallK Daykin
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieD L Simmons
Apr 1, 1991·The Journal of Allergy and Clinical Immunology·S MattoliA Fasoli
Jun 1, 1991·The American Review of Respiratory Disease·A S VathenenA E Tattersfield
Jun 20, 1989·European Journal of Pharmacology·C L ArmourJ L Black
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Jan 6, 1968·Nature·W J Sweatman, H O Collier
Feb 15, 1994·Biochemical and Biophysical Research Communications·R A RobbinsJ Polak
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J R VaneD A Willoughby
Aug 30, 1994·Biochemical and Biophysical Research Communications·R A RobbinsJ M Polak
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·K AsanoJ S Stamler
Aug 1, 1995·Thorax·A J Knox, A E Tattersfield
Jun 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C J GrossmanP J Birch
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·S A GreenS B Liggett
Feb 1, 1995·Journal of Applied Physiology·T BarryA Knox
Feb 18, 1995·Lancet·I D Pavord, A E Tattersfield
Mar 1, 1995·American Journal of Respiratory Cell and Molecular Biology·T EndoS Yamamoto
Jan 20, 1994·Nature·J Vane
Nov 1, 1993·American Journal of Respiratory Cell and Molecular Biology·S WiddopI P Hall
Dec 1, 1993·The American Review of Respiratory Disease·E IsraelJ M Drazen
Nov 1, 1993·Clinical Science·J H Campbell, G R Campbell
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·P SestiniM Robuschi

❮ Previous
Next ❯

Citations

Oct 27, 2007·Archives of Environmental Contamination and Toxicology·Ruijin LiJingfang Xie
Jun 21, 2005·Lasers in Medical Science·F AimbireM T T Pacheco
Aug 24, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Virginie Pétrilli, Fabio Martinon
Mar 15, 2005·Journal of Ethnopharmacology·Ming-Jiuan WuTzi-Wei Lian
Jan 5, 2002·European Journal of Pharmacology·N LazzeriJ A Mitchell
Sep 28, 1999·European Journal of Pharmacology·E BarchaszC Advenier
Aug 1, 1997·Trends in Pharmacological Sciences·S R Johnson, A J Knox
Aug 5, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michelle A CareyDarryl C Zeldin
Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·Catherine DuvernelleNelly Frossard
Nov 20, 2001·Current Opinion in Pharmacology·A L Lazaar, R A Panettieri
Oct 1, 2003·Respiratory Physiology & Neurobiology·Andrew J Halayko, Yassine Amrani
Oct 1, 2003·Respiratory Physiology & Neurobiology·William T Gerthoffer, Cherie A Singer
Oct 1, 2003·Respiratory Physiology & Neurobiology·Reynold A Panettieri
Oct 1, 2003·Respiratory Physiology & Neurobiology·Stuart J Hirst
Sep 14, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·M B SukkarP R Johnson
Jan 2, 2001·Mediators of Inflammation·M B SukkarC L Armour
Aug 25, 2000·Mediators of Inflammation·J M HughesC L Armour
Oct 15, 2008·Annual Review of Physiology·Omar Tliba, Reynold A Panettieri
Jan 17, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jamie K PatelAlan J Knox
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·P SongV Brusasco
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S J Hirst, T H Lee
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·P J Barnes
Apr 3, 2001·American Journal of Respiratory and Critical Care Medicine·J L PypeG M Verleden
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·M P HallsworthS J Hirst
Dec 9, 1998·American Journal of Respiratory Cell and Molecular Biology·M P HallsworthS J Hirst
Dec 15, 2007·American Journal of Respiratory Cell and Molecular Biology·Charlotte S MullanLinhua Pang
Jan 31, 2006·Respiratory Research·Cecilia KemiCaroline Olgart Höglund
Nov 3, 2012·RNA·Alexander KondrashovCornelia H De Moor
Feb 1, 2003·Biochemical and Biophysical Research Communications·Hidetoshi HayashiKikuo Onozaki
Dec 1, 1999·British Journal of Pharmacology·J A Mitchell, T D Warner
Jun 23, 2015·American Journal of Respiratory Cell and Molecular Biology·Nowshin N RumzhumAlaina J Ammit
May 30, 2008·The Journal of Investigative Dermatology·Syed M MeeranSantosh K Katiyar
Feb 14, 2012·Expert Opinion on Therapeutic Targets·Sanjay MalhotraSunanda Ghosh Dastidar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.