Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction.

Journal of Immunology Research
Montserrat Guadalupe Garza-ReyesAlicia Contreras-Rodríguez

Abstract

Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14 + CD16 - and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16- and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we dem...Continue Reading

References

Mar 26, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·John T ParissisDimitrios Th Kremastinos
Dec 15, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L N López-BojórquezA Zentella-Dehesa
Feb 20, 2007·Arthritis Research & Therapy·Steven K LundyDavid A Fox
Feb 26, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xiang ChengYu-Hua Liao
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang HuLionel B Ivashkiv
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian ErbelThomas J Dengler
Mar 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiva ShahraraRichard M Pope
Nov 26, 2011·Journal of the American College of Cardiology·Elisa A LiehnNikolaus Marx
Jan 13, 2012·Circulation. Cardiovascular Genetics·Katarina E BergHarry Björkbacka
Oct 16, 2013·European Heart Journal·Ulrich Hofmann, Stefan Frantz
Dec 12, 2013·Archives of Medical Research·Luis Chávez-SánchezFrancisco Blanco-Favela
Mar 26, 2014·Nature Reviews. Cardiology·Nikolaos G Frangogiannis
Sep 28, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian ErbelChristian A Gleissner
Jan 17, 2015·Circulation Research·Ulrich Hofmann, Stefan Frantz
Jul 15, 2015·The Journal of Clinical Investigation·Stephen E BoagIoakim Spyridopoulos
Jun 25, 2016·Circulation Research·Sumanth D Prabhu, Nikolaos G Frangogiannis
Jun 30, 2016·The Journal of Experimental Medicine·Anta NgkeloJean-Sébastien Silvestre
Oct 22, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Rachel M KratofilJustin F Deniset
May 26, 2017·The New England Journal of Medicine·Jeffrey L Anderson, David A Morrow
Oct 12, 2017·Lipids in Health and Disease·María de la Paz Sánchez-MartínezLuis Chávez-Sánchez
Jan 21, 2019·Molecular Immunology·Mónica Daniela Mora-RuízLuis Chávez-Sánchez

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Anastasia V PoznyakAlexander N Orekhov

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad Prism
FlowJo
GraphPad

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

The International Journal of Cardiovascular Imaging
Peter Yuan ZhangMiriam Shanks
Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Riemer H J A Slart, Luis Eduardo Juarez-Orozco
Arerugī = [Allergy]
© 2021 Meta ULC. All rights reserved