Abstract
B cell activating factor belonging to the tumor necrosis factor family (BAFF) is a cytokine, indispensable for B cell survival, maturation, and activation. Over-expression of BAFF leads to lupus like disease in mice and the serum level of BAFF is elevated in human lupus. However, little is known about BAFF synthesis and its regulation. In this study, we examined the effects of a series of inflammatory cytokines on BAFF production in human peripheral blood mononuclear cells (PBMCs) in vitro. We found interleukin-2 (IL-2) strongly and dose-dependently stimulated BAFF synthesis in PBMCs, and an anti-IL-2 antibody neutralized the effect. Furthermore, T and NK cells produced BAFF with IL-2 stimulation. From these observations, IL-2 is one of the regulatory cytokines having a positive effect on BAFF synthesis in human peripheral T and NK cells. Persistent over-production of IL-2 might lead to up-regulation of BAFF synthesis in PBMCs in pathological conditions such as lupus.
References
Oct 6, 1997·Science·G U von Bülow, R J Bram
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Jul 10, 1999·Science·P A MooreD M Hilbert
Jul 6, 2000·The Journal of Experimental Medicine·X Z XiaH Hsu
Aug 18, 2001·Science·J S ThompsonC Ambrose
Feb 14, 2006·Nature Reviews. Drug Discovery·Stacey R DillonAnne J Novak
Feb 25, 2006·Blood·Lingchen FuRichard J Ford
Jun 3, 2006·International Immunology·Keiko YoshimotoTsutomu Takeuchi
Citations
May 21, 2013·Cytokine & Growth Factor Reviews·Fabien B VincentFabienne Mackay
Oct 11, 2011·Rheumatology·Gro Ø EilertsenJohannes C Nossent
Jun 29, 2010·American Journal of Respiratory and Critical Care Medicine·Francesca PolverinoMarina Saetta
Mar 13, 2014·Nature Reviews. Rheumatology·Fabien B VincentFabienne Mackay
Jan 15, 2014·Cytokine & Growth Factor Reviews·Maogen ChenSong Guo Zheng
Jan 23, 2016·Rheumatology·Nicolyn ThompsonCoziana Ciurtin
Nov 15, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Harry AlexopoulosMarinos C Dalakas
Apr 6, 2016·Multidisciplinary Respiratory Medicine·Francesca PolverinoCaroline A Owen
Jun 16, 2015·American Journal of Respiratory and Critical Care Medicine·Francesca PolverinoCaroline A Owen
Feb 25, 2015·Leukemia·J WildH R Salih
Jun 1, 2016·La Presse médicale·Jacques-Olivier Pers, Alain Saraux
Jan 1, 2010·Journal of Zhejiang University. Science. B·Jian LiuShu-sheng Liu
Sep 10, 2020·Expert Opinion on Therapeutic Targets·Roberta MagliozziMassimiliano Calabrese
Feb 21, 2019·Experimental and Therapeutic Medicine·Francisco Josué Carrillo-BallesterosClaudia Azucena Palafox-Sánchez
Dec 18, 2020·Autoimmunity Reviews·Tamara MöckelAndreas Schwarting