Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells

Cytokine
Katsuya SuzukiTsutomu Takeuchi

Abstract

B cell activating factor belonging to the tumor necrosis factor family (BAFF) is a cytokine, indispensable for B cell survival, maturation, and activation. Over-expression of BAFF leads to lupus like disease in mice and the serum level of BAFF is elevated in human lupus. However, little is known about BAFF synthesis and its regulation. In this study, we examined the effects of a series of inflammatory cytokines on BAFF production in human peripheral blood mononuclear cells (PBMCs) in vitro. We found interleukin-2 (IL-2) strongly and dose-dependently stimulated BAFF synthesis in PBMCs, and an anti-IL-2 antibody neutralized the effect. Furthermore, T and NK cells produced BAFF with IL-2 stimulation. From these observations, IL-2 is one of the regulatory cytokines having a positive effect on BAFF synthesis in human peripheral T and NK cells. Persistent over-production of IL-2 might lead to up-regulation of BAFF synthesis in PBMCs in pathological conditions such as lupus.

Citations

May 21, 2013·Cytokine & Growth Factor Reviews·Fabien B VincentFabienne Mackay
Jun 29, 2010·American Journal of Respiratory and Critical Care Medicine·Francesca PolverinoMarina Saetta
Mar 13, 2014·Nature Reviews. Rheumatology·Fabien B VincentFabienne Mackay
Jan 15, 2014·Cytokine & Growth Factor Reviews·Maogen ChenSong Guo Zheng
Nov 15, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Harry AlexopoulosMarinos C Dalakas
Jun 16, 2015·American Journal of Respiratory and Critical Care Medicine·Francesca PolverinoCaroline A Owen
Jun 1, 2016·La Presse médicale·Jacques-Olivier Pers, Alain Saraux
Sep 10, 2020·Expert Opinion on Therapeutic Targets·Roberta MagliozziMassimiliano Calabrese
Feb 21, 2019·Experimental and Therapeutic Medicine·Francisco Josué Carrillo-BallesterosClaudia Azucena Palafox-Sánchez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.