Effect of interleukin-4 on peripheral blood leukocytes in rats with various behavioral characteristics during acute stress

Bulletin of Experimental Biology and Medicine
S S PertsovL S Kalinichenko

Abstract

We studied the effect of anti-inflammatory cytokine IL-4 (5 μg/kg intraperitoneally) on peripheral blood leukocytes in Wistar rats with various behavioral characteristics during acute emotional stress (1-h immobilization with simultaneous subthreshold electrocutaneous stimulation). IL-4 reduced the differences in blood leukocyte count in rats with various behavioral characteristics, which was related to a significant decrease in this parameter in active animals. IL-4 injection to active animals was accompanied by changes in the leukogram (development of neutrophilia, monocytopenia, and lymphopenia) and had a modulatory effect on leukocyte indexes of cell reactivity. Blood leukocyte count in cytokine-treated animals did not change after stress exposure. IL-4 prevented shifts in leukocyte indexes of cell reactivity, which was found after acute stress exposure. Our results expand current notions on the specific involvement of endogenous immunomodulatory compounds in the realization of adaptive and compensatory processes in mammals during negative emotiogenic exposures.

References

Apr 9, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·S S PertsovG V Pirogova
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jonathan P Godbout, Ronald Glaser
Dec 23, 2009·Bulletin of Experimental Biology and Medicine·S S PertsovA S Simbirtsev
Nov 1, 2013·World Journal of Psychiatry·Pia Koudouovoh-Tripp, Barbara Sperner-Unterweger
Nov 14, 2013·Frontiers in Physiology·Chun-Jung HuangEdmund O Acevedo
Dec 10, 2013·Bulletin of Experimental Biology and Medicine·L S KalinichenkoE V Koplik
Apr 29, 2014·Bulletin of Experimental Biology and Medicine·E V KoplikL S Kalinichenko
Apr 29, 2014·Bulletin of Experimental Biology and Medicine·L S KalinichenkoS S Pertsov

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Citations

Jul 2, 2016·Developmental Psychobiology·Maria Beatriz Barreto do CarmoMaria Helena Leite Hunziker
Dec 7, 2018·Journal of Zhejiang University. Science. B·Supatcharee ArunSitthichai Iamsaard

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