PMID: 2497288Jan 1, 1989Paper

Effect of intermittent exposure and drug-free intervals on the in vitro vascular tolerance to nitroglycerin

Life Sciences
E KowalukH L Fung

Abstract

Recent reports suggest that intermittent nitroglycerin (NTG) treatment, incorporating a daily nitrate-free interval, can avoid the tolerance associated with continuous NTG therapy. This study has investigated whether an in vitro model of NTG tolerance could be used to examine the mechanisms of tolerance avoidance (by intermittent NTG exposure) and tolerance reversal. Isolated rat abdominal aortic rings were exposed to 55 microM NTG at varying intervals over a 60 min period, and the concentration-relaxation curves to NTG were subsequently determined. Intermittent NTG exposure (either 12 x 0.5 min or 3 x 2 min) significantly reduced NTG tolerance compared to continuous exposure over the same period of time (60 min). The diminished tolerance was apparently due to the reduced total exposure time, since the NTG responsiveness of aortic rings exposed to NTG intermittently or continuously for 6 min of the incubation period was not significantly different. Under the present conditions, in vitro NTG tolerance could be reversed if sufficient washout time was allowed. Thus, aortic rings exposed to NTG for the initial, but not the final, 6 min of incubation were not tolerant to NTG. In addition, rings exposed to NTG for 3 min exhibited nea...Continue Reading

References

Jun 1, 1988·Circulation·D ZimrinH L Fung

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Citations

Nov 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·P V SergeevV E Trepilets
Jun 1, 1994·Cardiovascular Drugs and Therapy·H L Fung, J A Bauer
Aug 1, 1992·Current Problems in Cardiology·J Abrams

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