Effect of intermittent systemic administration of recombinant parathyroid hormone (1-34) on mandibular fracture healing in rats

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Henry H RowshanJose M Pizarro

Abstract

To establish a rat mandibular fracture model and investigate the short- and long-term effects of recombinant parathyroid hormone (PTH 1-34) on mandibular fracture healing in rats. A controlled unilateral mandibular fracture was created surgically in 29 male Sprague-Dawley rats and then stabilized using an external fixation device. The rats were divided into 2 groups: 1 group received daily subcutaneous injections of 10 microg/kg of PTH(1-34) and 1 group served as the vehicle control. The rats were killed on postoperative days 7 and 21, and radiographic densitometry and histologic evaluation of new bone formation were performed. A novel unilateral mandibular fracture model was established that has significant differences from previously published models, both in the location of the osteotomy site and in the rigid external stabilization device. The PTH(1-34) treated rats showed a statistically significant difference (P < .05) in callous formation compared with the control animals. Radiographic densitometry evaluation of the injury site revealed an increase in bone density, apparent at day 7 in the experimental group. Visual inspection of the histologic sections stained with Masson's trichrome blue showed an apparent increase in n...Continue Reading

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Citations

Oct 19, 2010·The New England Journal of Medicine·Andrew Grey
Oct 17, 2012·Journal of Dental Research·H L Chan, L K McCauley
Sep 28, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Zheng-Long TangDan-Rong Wu
Mar 5, 2016·Clinical Orthopaedics and Related Research·Mohit BhandariBruce Mitlak
Mar 29, 2014·Journal of Biomedical Materials Research. Part a·Liliana R Missana, María V Jammal
Mar 11, 2015·BioMed Research International·Tsan-Wen HuangRobert Wen-Wei Hsu
Nov 29, 2014·Current Osteoporosis Reports·J Tracy Watson, Daemeon A Nicolaou
Jul 13, 2016·BMC Medicine·Ippokratis PountosPeter V Giannoudis
Jun 7, 2013·Brazilian Oral Research·Marília Pacífico LucisanoLea Assed Bezerra da Silva
Feb 17, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey J HsuYin Tintut
Sep 19, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Fumihiko KajiiShinji Kamakura
Dec 30, 2015·Journal of Bone Metabolism·Gun-Il Im, Seong-Hyun Lee
Aug 18, 2020·Tissue Engineering. Part a·Keiko MatsuiShinji Kamakura
Mar 5, 2013·Journal of Orthopaedic Trauma·Dafang ZhangJoseph Lane
Sep 11, 2020·Journal of Bone Metabolism·Byung-Ho Yoon, Ki-Choul Kim
May 1, 2012·Clinical Advances in Periodontics·Jill D BashutskiRobert M Eber
Jan 2, 2021·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Cansu Gül Koca, Meryem Kösehasanoğulları
Jul 20, 2021·Tissue Engineering. Part a·Atsumu KouketsuShinji Kamakura

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