Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis

Multiple Sclerosis and Related Disorders
Kathryn C FitzgeraldEllen M Mowry

Abstract

An intermittent fasting or calorie restriction diet has favorable effects in the mouse forms of multiple sclerosis (MS) and may provide additional anti-inflammatory and neuroprotective advantages beyond benefits obtained from weight loss alone. We conducted a pilot randomized controlled feeding study in 36 people with MS to assess safety and feasibility of different types of calorie restriction (CR) diets and assess their effects on weight and patient reported outcomes in people with MS. Patients were randomized to receive 1 of 3 diets for 8 weeks: daily CR diet (22% daily reduction in energy needs), intermittent CR diet (75% reduction in energy needs, 2 days/week; 0% reduction, 5 days/week), or a weight-stable diet (0% reduction in energy needs, 7 days/week). Of the 36 patients enrolled, 31 (86%) completed the trial; no significant adverse events occurred. Participants randomized to CR diets lost a median 3.4 kg (interquartile range [IQR]: -2.4, -4.0). Changes in weight did not differ significantly by type of CR diet, although participants randomized to daily CR tended to have greater weight loss (daily CR: -3.6 kg [IQR: -3.0, -4.1] vs. intermittent CR: -3.0 kg [IQR: -1.95, -4.1]; P = 0.15). Adherence to study diets differed s...Continue Reading

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Citations

May 23, 2019·Neurodegenerative Disease Management·Dejan JakimovskiRobert Zivadinov
Nov 16, 2018·Neurology·Ruth Ann MarrieAlberto Ascherio
Feb 28, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Michael D Kornberg
May 15, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Claire ValburgAsaff Harel
Dec 28, 2019·The New England Journal of Medicine·Rafael de Cabo, Mark P Mattson
Aug 9, 2019·Annals of Clinical and Translational Neurology·Emmanuelle WaubantAnnette Langer-Gould
Aug 4, 2019·Biogerontology·Sudhakar Krittika, Pankaj Yadav
Oct 28, 2019·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Claudia H MarckGeorge A Jelinek
Oct 10, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Kathryn C Fitzgerald, Ellen M Mowry
Aug 22, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Claudia CantoniLaura Piccio
Feb 6, 2020·Physiology & Behavior·Kai LiuLeonie K Heilbronn
Aug 16, 2021·Journal of Chemical Neuroanatomy·Davood ZariniIraj Ragerdi Kashani
Aug 31, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Karlien VeldscholteSascha C A T Verbruggen
Sep 30, 2021·Current Neurology and Neuroscience Reports·Sergio A Ramírez-SalazarJorge G Ortiz García
Oct 12, 2021·Annual Review of Nutrition·Krista A VaradyKelsey Gabel
Nov 11, 2019·Multiple Sclerosis and Related Disorders·Kathryn C FitzgeraldEllen M Mowry
May 15, 2020·Multiple Sclerosis and Related Disorders·S N RomanE M Mowry

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