Effect of intermittent weight bearing on soleus fiber force-velocity-power and force-pCa relationships

Journal of Applied Physiology
J J BangartR H Fitts

Abstract

Rat permeabilized type I soleus fibers displayed a 33% reduction in peak power output and a 36% increase in the free Ca2+ concentration required for one-half maximal activation after 14 days of hindlimb non-weight bearing (NWB). We examined the effectiveness of intermittent weight bearing (IWB; consisting of four 10-min periods of weight bearing/day) as a countermeasure to these functional changes. At peak power output, type I fibers from NWB animals produced 54% less force and shortened at a 56% greater velocity than did type I fibers from control weight-bearing animals while type I fibers from the IWB rats produced 26% more absolute force than did fibers from the NWB group and shortened at a velocity that was only 80% of the NWB group mean. As a result, no difference was observed in the average peak power of fibers from the IWB and NWB animals. Hill plot analysis of force-pCa relationships indicated that fibers from the IWB group required similar levels of free Ca2+ to reach half-maximal activation in comparison to fibers from the weight-bearing group. However, at forces < 50% of peak force, the force-pCa curve for fibers from the IWB animals clearly fell between the relationships observed for the other two groups. In summary...Continue Reading

References

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Citations

Jun 16, 2001·Journal of Applied Physiology·K Yamashita-GotoT Yoshioka
May 4, 2004·Journal of Applied Physiology·Jason C GalleglyEsther E Dupont-Versteegden
Apr 15, 2008·Medicine and Science in Sports and Exercise·Mitsunori MiyazakiTohru Takemasa
Aug 5, 2000·Journal of Applied Physiology·R H FittsJ J Widrick
Jan 1, 2003·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki Yamazaki
Oct 30, 2012·Journal of Applied Physiology·Jong-Hee Kim, Ladora V Thompson
Jan 1, 2001·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino
May 9, 2002·American Journal of Physiology. Cell Physiology·Esther E Dupont-VersteegdenCharlotte A Peterson
Oct 8, 2004·American Journal of Physiology. Cell Physiology·D A RileyR H Fitts
Apr 14, 1999·The Journal of Physiology·J J WidrickR H Fitts
Jan 11, 2005·Journal of Applied Physiology·John CarusoSteve Siconolfi
Jun 26, 2013·Journal of Strength and Conditioning Research·James L Nuzzo, Jeffrey M McBride
Jun 12, 2008·Journal of Strength and Conditioning Research·John F CarusoDean R Mercado

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