Effect of Interval and Continuous Aerobic Training on Basal Serum and Plasma Brain-Derived Neurotrophic Factor Values in Seniors: A Systematic Review of Intervention Studies

Rejuvenation Research
Lievyn EnettePierre Olivier Lang

Abstract

The purpose of this systematic review was to provide a comprehensive analysis of the available clinical trials analyzing, in seniors, the effect of interval aerobic training (IAT) and continuous aerobic training (CAT) on peripheral brain-derived neurotrophic factor (BDNF) concentration. We identified 14 randomized or not-randomized intervention studies published up to January 2017 through a computer-assisted search (PUBMED, Pedro, and Science direct data bases). The five trials considering IAT and the nine considering CAT totalized 988 individuals (age range: 58.1-77 years). The parameters of aerobic training (AT) protocol in terms of frequency and intensity are the primary determinants of the BDNF response to AT. The interpretation of the relationship between AT and BDNF signaling pathway was very challenging when specific health conditions were taken into consideration. This was more particularly true with mild cognitive impairment or depressive symptoms. These findings argue in favor of a generalization of the practice of AT and show that the type of training is not the main determining factor of the increase in BDNF level, which results more from the combination of several factors such as intensity and frequency of sessions...Continue Reading

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Citations

Mar 24, 2020·The International Journal of Neuroscience·Entesar Yaseen Abdo QaidTeguh Haryo Sasongko
Apr 25, 2020·Journal of Clinical Medicine·Patrick MüllerNotger G Müller
Jan 17, 2020·Current Pharmaceutical Design·Daniela Sayuri InoueFábio Santos Lira
Jan 11, 2020·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Lievyn EnettePierre Olivier Lang

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