Effect of intra-articular injection of levobupivacaine on articular cartilage and synovium in rats.

Der Anaesthesist
I A ErdenU Aypar

Abstract

Intra-articular local anesthetics are often used for prevention of pain after arthroscopic knee surgery. However, the effect of local anesthetics other than bupivacaine on articular cartilage and synovium has not been studied. Also, complications associated with the injection of intra-articular bupivacaine have appeared in the literature. The aim of this study was to evaluate the effects of levobupivacaine on the articular cartilage and the synovium in rats. Under aseptic conditions 0.25 ml (5 mg/ml) of levobupivacaine was injected into the right knee joint while 0.25 ml of saline was simultaneously injected into the left knee joint of 20 adult Sprague-Dawley rats. The purpose of saline injections was to serve as a control group. Groups of five rats were killed on days 1, 7, 14 and 21 after administration of injections. The knee joint samples were evaluated for the presence of inflammation in the articular and periarticular tissues and the synovium. There were no significant differences between the levobupivacaine and control groups with respect to inflammation in the articular and periarticular tissues and the synovium. Although more studies are needed before final recommendations can be made, by evaluating the results obtaine...Continue Reading

References

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Aug 15, 2006·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Andreas H GomollBrian J Cole

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Citations

Apr 15, 2014·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Klemen RavniharMatej Drobnič
Mar 29, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Cengiz IsikTuran Duran
Oct 4, 2016·Revista brasileira de anestesiologia·Mustafa Soner ÖzcanFeyhan Ökten
May 11, 2018·BMC Anesthesiology·Aysun Ankay YilbasFatma Saricaoglu

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