Effect of intra-coronary nicorandil administration prior to reperfusion in acute ST segment elevation myocardial infarction

Circulation Journal : Official Journal of the Japanese Circulation Society
Han Cheol LeeSang-Kwon Lee

Abstract

Intravenous nicorandil infusion with percutaneous coronary intervention (PCI) has been reported to reduce reperfusion injury events and improve cardiac function in patients with acute myocardial infarction (MI). However, there is limited information on the use of intracoronary nicorandil. In the present study, 73 patients with acute ST segment elevation MI undergoing PCI were randomly assigned to the Nicorandil Group (n=37) or the Control Group (n=36). The composite endpoints were the incidences of ventricular arrhythmia, no-reflow and slow flow. A significant difference in the composite endpoint was observed in the Nicorandil Group when compared with the Control Group (p=0.037). The occurrence of post Thrombolysis In Myocardial Infarction (TIMI) grade 3 was significantly higher in the Nicorandil Group (p=0.019). Major adverse cardiac events during hospitalization and within 30 days of treatment were similar between the 2 groups. Administration of intracoronary nicorandil reduced the occurrence of no-reflow, slow reflow, and reperfusion arrhythmia, and improved the myocardial perfusion grade, TIMI flow during PCI and improved clinical outcomes in patients with acute MI.

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Citations

Sep 5, 2013·Cardiovascular Intervention and Therapeutics·Maki OiTakeshi Kimura
Jul 9, 2014·Pharmacology & Therapeutics·Giacinta GuariniMario Marzilli
Jan 19, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Shigeo HorinakaUNKNOWN JCAD Study Investigators
Mar 18, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Noritoshi ItoToru Hayashi
Jan 25, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Atsushi HirohataTohru Ohe
Oct 16, 2010·Cardiovascular Therapeutics·Sharon L HaleRobert A Kloner
Jun 13, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Joo Myung LeeNobukiyo Tanaka
May 19, 2012·Expert Opinion on Pharmacotherapy·Vikram SharmaDerek M Yellon
Dec 15, 2010·Journal of Cardiovascular Translational Research·Stavros StavrakisJohn Nanas
Sep 5, 2018·Nature Reviews. Cardiology·Massimo BonoraLorenzo Galluzzi
Dec 19, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Weiding WangTong Liu

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