Effect of intracerebroventricular and intravenous administration of nitric oxide donors on blood pressure and heart rate in anaesthetized rats

British Journal of Pharmacology
M L Nurminen, H Vapaatalo

Abstract

1. The effects of nitric oxide (NO) releasing substances, sodium nitroprusside, 3-morpholino sydnonimine (SIN-1) and a novel oxatriazole derivative, GEA 3162, on blood pressure and heart rate were studied after peripheral or central administration in anaesthetized normotensive Wistar rats. 2. Given as cumulative intravenous injections, both nitroprusside and GEA 3162 (24-188 nmol kg-1) induced short-lasting and dose-dependent decreases in mean arterial pressure, while SIN-1 decreased blood pressure only slightly even after larger doses (94-3000 nmol kg-1). Heart rate increased concomitantly with the hypotensive effect of the NO-releasing substances. 3. Cumulative intracerebroventricular administration of GEA 3162 (24-188 nmol kg-1) induced a dose-dependent hypotension with slight but insignificant increases in heart rate. In contrast, intracerebroventricular nitroprusside induced little change in blood pressure, while a large dose of SIN-1 (3000 nmol kg-1, i.c.v.) slightly increased mean arterial pressure. However, intracerebroventricular nitroprusside and SIN-1 increased heart rate at doses that did not significantly affect blood pressure. 4. To determine whether the cardiovascular effects of GEA 3162 were attributable to an e...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·S Ma, J P Long
Aug 1, 1992·British Journal of Pharmacology·R J GryglewskiJ R Vane
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Aug 1, 1992·Neuropharmacology·G CalapaiA P Caputi
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Oct 28, 1991·Neuroscience Letters·L N ShapovalL S Pobegailo
Jan 1, 1991·British Journal of Pharmacology·P K MooreS L Hart
Jan 1, 1989·Journal of Cardiovascular Pharmacology·M FeelischE Noack
Jan 5, 1995·Biochemical and Biophysical Research Communications·C Cabrera, D Bohr
Feb 1, 1996·British Journal of Pharmacology·H KankaanrantaT Metsä-Ketelä

❮ Previous
Next ❯

Citations

May 3, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·María TorrecillaJoseba Pineda
Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Jan 13, 2006·Clinical and Experimental Pharmacology & Physiology·Daryl O SchwenkeMikiyasu Shirai
May 9, 2002·Expert Opinion on Investigational Drugs·Ian L Megson, David J Webb
Sep 6, 2005·Brain Research Bulletin·Ana Cristina R LacerdaCândido C Coimbra
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J G P PiresH A Futuro Neto
Mar 23, 2005·Neuroscience and Behavioral Physiology·M A GilinskiiV V Bulygina
Jul 20, 2002·Journal of Toxicology. Clinical Toxicology·Yesim TuncokSerdar Kurt
Nov 24, 2004·Clinical and Experimental Hypertension : CHE·Chris G SchyvensJudith A Whitworth
Apr 11, 2002·Chemical Reviews·Peng George WangAdam J Janczuk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.