Effect of intragastric injection of botulinum toxin A for the treatment of obesity: a meta-analysis and meta-regression

Gastrointestinal Endoscopy
Chang Seok BangDong Joon Kim

Abstract

Controversies persist regarding the effect of intragastric injection of botulinum toxin A for the treatment of obesity. To assess the efficacy of intragastric botulinum toxin injection for the treatment of obesity. A systematic literature review was conducted by using the core databases. Pre- and posttreatment body weight data were extracted and analyzed by using Hedges' g. A random-effects model was applied. The methodological quality of the enrolled studies was assessed by the risk of bias table and Newcastle-Ottawa Scale. Publication bias was evaluated via the funnel plot, trim and fill method, Egger's test, and rank correlation test. Meta-analysis of 8 studies. A total of 115 patients (79 treated vs 36 placebo). Intragastric botulinum toxin A injection. Hedges' g, calculated from pre- and posttreatment body weight data and comparison of body weight changes between treatment and placebo group. The treatment group was associated with weight loss in a pre/post comparative approach and compared with the placebo group (Hedges' g: -0.443; 95% confidence interval, -0.845 to -0.040; P = .031; and Hedges' g: -0.521; 95% confidence interval, -0.956 to -0.085; P = .019). Wide area injection including the fundus or body rather than the...Continue Reading

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