PMID: 2492823Feb 6, 1989Paper

Effect of intralipid infusion on lecithin:cholesterol acyltransferase and lipoprotein lipase in young rats

Biochimica Et Biophysica Acta
S AmrM Hamosh

Abstract

We compared the effects of Intralipid and dextrose infusion on plasma lecithin:cholesterol acyltransferase (LCAT), plasma lipid profiles and lipolytic activity. We used 5-week-old male Sprague-Dawley rats which were given total parenteral nutrition (TPN) with either Intralipid (3 g/kg body weight) or an equicaloric amount of 25% dextrose in the presence or absence of heparin (1 or 10 IU/ml of TPN). 40 min after the end of 4 h of infusion, plasma LCAT activity was significantly decreased (P less than 0.001), while total cholesterol and free fatty acid levels were significantly (P less than 0.05) increased in rats given Intralipid as compared to those given dextrose. We found associations (P less than 0.005) between LCAT activity and total cholesterol and between LCAT and free fatty acid levels; the coefficients of negative correlation were 0.543 and 0.607, respectively. Concomitantly to the increment in plasma total cholesterol levels, there was a decrease in the high-density lipoprotein (HDL) cholesterol fraction; the latter, which was 40% of the total plasma cholesterol in control and dextrose-infused rats, declined to 9% in rats given Intralipid. Administration of heparin during Intralipid infusion, even up to 10 IU/ml of TPN...Continue Reading

References

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Citations

Jan 29, 2013·Biochimica Et Biophysica Acta·Amirhossein Sahebkar
Nov 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·M EkelundP Nilsson-Ehle
Feb 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M Richelle
May 27, 2008·Chemistry and Physics of Lipids·Daniel L SparksNihar R Pandey

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