Effect of intraluminal pH on the release of somatostatin and gastrin into antral, bulbar and ileal pouches of conscious dogs

Acta Physiologica Scandinavica
K Uvnäs-WallenstenP D Cranwell

Abstract

Experiments were performed on conscious dogs with chronic pouches of the antrum, the duodenal bulb or the ileum, which were perfused with solutions of varying pH. Gastrin and somatostatin levels were measured in the perfusates. When the pouches were perfused with 0.15 M NaCl only small amounts of gastrin and somatostatin (1 pmol/min) were released into the lumen of the antrum and of the duodenal bulb. By lowering pH of the perfusion fluid a pH dependent release of somatostatin was induced into the lumen of the antrum and the duodenal bulb. Perfusion with 0.1 M HCl caused a large output of somatostatin (6--60 pmol/min) into the pouches. The upper pH limit for stimulation of the intraantral or intrabulbar somatostatin release appeared to be approximately pH 3--4. Somatostatin was also released into ileal perfusates at intraluminal pHs below 3--4. Lowering of pH in the antral pouches caused an increased intraluminal gastrin release, which was quantitatively less impressive than that of somatostatin. Occasionally also the gastrin release into the duodenal bulb increased during perfusion with 0.1 M HCl, whereas no such release was induced by acidification of the lumen of the ileum. It is suggested that the inhibition of gastrin rele...Continue Reading

References

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Citations

Apr 6, 2004·Journal of Theoretical Biology·Ian M Joseph, Denise Kirschner
Apr 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Milena Saqui-SalcesJuanita L Merchant
Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·R K RaoO Koldovsky
Apr 1, 1986·Gut·M R Lucey
Nov 16, 2002·Journal of Applied Physiology·Ian M P JosephDenise Kirschner
Apr 1, 1984·The American Journal of Physiology·G PittengerL Wagner
Oct 19, 2021·Molecular Metabolism·Emily L MiedzybrodzkaFiona M Gribble

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