Effect of intramuscular administration of medetomidine and xylazine on tear flow measured by the Schirmer tear test I in healthy cats

Journal of Feline Medicine and Surgery
Teppei KandaToshinori Furukawa

Abstract

This study aimed to investigate the effects of intramuscular medetomidine and xylazine on tear flow in healthy cats. Five cats each received medetomidine 10, 20, 40 and 80 µg/kg IM; xylazine 1.0, 2.0, 4.0 and 8.0 mg/kg IM; and physiological saline (2.0 ml IM) in a randomised order separated by intervals of at least 1 week. The Schirmer tear test (STT) I was performed in both eyes before and 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, 6, 7, 8 and 24 h after each dose. The STT I value decreased significantly at 0.5 and 1.0 h and at 0.75 and 1.0 h in both eyes after administration of medetomidine at 10 or 40 µg/kg. After administration of medetomidine 80 µg/kg, there was a significant decrease in the STT I reading at 0.75, 2 and 3 h in the left eye and 0.75, 1, 2 and 3 h in the right eye. The STT I value decreased significantly at: 0.5, 0.75, 1 and 2 h in the left eye and 0.75 h in the right eye after administration of xylazine 1.0 mg/kg; 0.5, 0.75, 1 and 2 h in the left eye and 0.5, 0.75, 1 and 3 h in the right eye after administration of xylazine 2.0 mg/kg; 0.5, 0.75, 1 and 2 h in both eyes after administration of xylazine 4.0 mg/kg; and 0.5, 0.75, 1, 2 and 3 h in the left eye and 0.75, 1, 2, 3 and 4 h in the right eye after administration ...Continue Reading

References

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Feb 27, 2016·American Journal of Veterinary Research·Simona Di PietroAntonio Pugliese

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Citations

Feb 13, 2019·The Journal of Veterinary Medical Science·Teppei KandaToshinori Furukawa
May 28, 2020·Acta Veterinaria Scandinavica·Jéssica Fontes VelosoRenata Santiago Alberto Carlos
Apr 17, 2020·Veterinary Sciences·Teppei KandaToshinori Furukawa

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BETA
sedation

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Graphpad Prism

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