Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice

Clinical and Diagnostic Laboratory Immunology
T HoriH Yasui

Abstract

In mice administered Lactobacillus casei strain Shirota (LcS) intranasally, potent induction of interleukin 12, gamma interferon, and tumor necrosis factor alpha, which play a very important role in excluding influenza virus (IFV), was evident in mediastinal lymph node cells. In this model of upper respiratory IFV infection, the titers of virus in the nasal wash of mice inoculated with 200 microg of LcS for three consecutive days (LcS 200 group) before infection were significantly (P < 0.01) lower than those of mice not inoculated with LcS (control group) (10(0.9 +/- 0.6) versus 10(2.1 +/- 1.0)). The IFV titer was decreased to about 1/10 of the control level. Using this infection model with modifications, we investigated whether the survival rate of mice was increased by intranasal administration of LcS. The survival rate of the mice in the LcS 200 group was significantly (P < 0.05) greater than that of the mice in the control group (69% versus 15%). It seems that the decrease in the titer of virus in the upper respiratory tract to 1/10 of the control level was important in preventing death. These findings suggest that intranasal administration of LcS enhances cellular immunity in the respiratory tract and protects against infl...Continue Reading

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Citations

Sep 20, 2005·Parasitology Research·C R Bautista-GarfiasJ Mosqueda
Dec 4, 2003·Research in Microbiology·Maria Mercedes TestaIda Laura Benito de Cardenas
Jan 5, 2002·Clinical and Diagnostic Laboratory Immunology·Tetsuji HoriHisako Yasui
Mar 19, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L LehtorantaR Korpela
Jan 10, 2016·Toxicon : Official Journal of the International Society on Toxinology·Layze C A da SilvaFranklin Riet-Correa
Jan 24, 2015·Geriatrics & Gerontology International·Hiroyasu AkatsuMitsuo Maruyama
Jul 6, 2010·International Immunopharmacology·Takayuki IzumoYoshinobu Kiso
Mar 14, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Katja HatakkaAnne Pitkäranta
Oct 27, 2015·Frontiers in Microbiology·Derrick R SamuelsonJudd E Shellito
Jun 6, 2013·Mediators of Inflammation·Esmaeil MortazJohan Garssen
May 6, 2020·Critical Reviews in Food Science and Nutrition·Chengcheng RenPaul de Vos
Sep 21, 2018·PLoS Neglected Tropical Diseases·Derick Nii Mensah OsakunorFrancisca Mutapi
Dec 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stanislaw J GabryszewskiHelene F Rosenberg

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