Effect of intranasal growth hormone-releasing hormone and corticotropin-releasing hormone administration on growth hormone and cortisol release: improved bioavailability by means of sodium-glycocholate

The Journal of Clinical Endocrinology and Metabolism
A E PontiroliG Pozza

Abstract

Several peptide hormones are effective when administered intranasally (in); these include oxytocin, vasopressin, insulin, glucagon, and calcitonin. With regard to GHRH and CRH, previous studies demonstrated that their bioavailability following in administration was very low. In this study we evaluated the serum GH response to 50 micrograms GHRH iv and to 700 micrograms GHRH in, the latter given alone and with 5 and 15 mg sodium-glycocholate (SGC), a surfactant, in six normal men. The bioavailability of in GHRH, calculated as net GH secretory area, was very low, and increased to 7% that of iv GHRH when SGC was used. In the same men, 50 micrograms CRH was administered both iv and in, alone and with 5 and 15 mg SGC. The bioavailability of in CRH, calculated as net cortisol secretory area, was very low and increased to 100% that of iv CRH when 15 mg SGC was used. These data indicate that the efficacy of GHRH and CRH administered in is significantly augmented by SGC.

Citations

May 20, 1999·International Journal of Pharmaceutics·E BechgaardL Martinsen
Nov 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A E Pontiroli, G Pozza
Jan 1, 1993·The Journal of Pediatric Endocrinology·L C Low
Mar 1, 1991·Journal of the American Geriatrics Society·M Kelijman
Feb 26, 2004·The Journal of Pharmacy and Pharmacology·Tianzhi YangFakhrul Ahsan
Nov 13, 1998·Journal of Pharmaceutical Sciences·A C ChaoJ A Fix

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