Effect of intranasal triamcinolone acetonide on bronchial hyper-responsiveness in children with seasonal allergic rhinitis and comparison of perceptional nasal obstruction with acoustic rhinometric assessment

International Journal of Pediatric Otorhinolaryngology
Fadil OztürkN Münevver Pinar

Abstract

Many patients with allergic rhinitis (AR) have bronchial hyper-responsiveness (BHR), and seasonal variation of BHR has been demonstrated in these patients. We aimed to investigate how BHR in children with seasonal AR is modified by triamcinolone acetonide aqueous nasal spray (TANS) therapy during the pollen season. A secondary aim was to assess the efficacy of TANS on nasal congestion by acoustic rhinometry and symptom scores. A total of 34 children aged 7-18 years with grass pollen-induced AR and 18 age and sex-matched healthy controls were included in study. The patients were divided into the following two subgroups: 22 patients who had AR only; and 12 patients who had AR and asthma. All of them had a baseline BHR (PC20FEV1 methacholine < 8mg/ml). All patients received 220 microg TANS once daily for 4 weeks following a 1-week run-in period. Nasal patency was measured by acoustic rhinometry and patients recorded their nasal obstruction scores in a diary. There was no significant difference at baseline pulmonary function test parameters between the patients and the healthy control children. None of the control subjects had BHR. Asthmatic children with AR had significantly reduced baseline PC20FEV1 when compared with the AR only...Continue Reading

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Citations

Aug 21, 2013·Paediatric Drugs·Olympia A TsilochristouNikolaos G Papadopoulos
Apr 27, 2005·International Journal of Pediatric Otorhinolaryngology·Fazil Orhan, Bulent Enis Sekerel
Oct 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Z M MunkJ A Smith
Aug 2, 2007·Current Medical Research and Opinion·William StormsLeonard Fromer
Mar 16, 2011·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·L E HaavistoJ I Sipilä
Nov 12, 2010·American Journal of Rhinology & Allergy·Anne Marie SalapatekSantosh T Varghese
Sep 8, 2006·American Journal of Rhinology·Débora Mery OuriquesLuc Louis Maurice Weckx
Oct 27, 2006·American Journal of Rhinology·Derek J LamEdward M Weaver
Feb 16, 2008·American Journal of Rhinology·Sune P StraszekPeter J Franklin
Jun 7, 2013·Korean journal of pediatrics·Abolfazl MahyarMousa Talebi-Bakhshayesh

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