Effect of intraoperative intravenous crystalloid infusion on postoperative nausea and vomiting after gynaecological laparoscopy: comparison of 30 and 10 ml kg(-1)

British Journal of Anaesthesia
J J MagnerD Buggy

Abstract

I.V. fluid administration has been shown to reduce postoperative nausea and vomiting (PONV). The optimum dose is unknown. We tested the hypothesis that administration of i.v. crystalloid of 30 ml kg(-1) would reduce the incidence of PONV compared with 10 ml kg(-1) of the same fluid. A total of 141 ASA I female patients undergoing elective gynaecological laparoscopy were randomized, in double-blind fashion, to receive either 10 ml kg(-1) (n=71; CSL-10 group) or 30 ml kg(-1) (n=70; CSL-30 group) of i.v. compound sodium lactate (CSL). In the first 48 h after anaesthesia, the incidence of vomiting was lower in the CSL-30 group than in the CSL-10 group (8.6% vs 25.7%, P=0.01). Anti-emetic use was less in the CSL-30 group at 0.5 h (2.9% vs 14.3%, P=0.04). The incidence of severe nausea was significantly reduced in the treatment group at awakening (2.9% vs 15.7%, P=0.02), 2 h (0.0% vs 8.6%, P=0.04) and cumulatively (5.7% vs 27.1%, P=0.001). The numbers needed to treat to prevent vomiting, severe nausea and antiemetic use in the first 48 h were 6, 5 and 6, respectively. I.V. administration of CSL 30 ml kg(-1) to healthy women undergoing day-case gynaecological laparoscopy reduced the incidence of vomiting, nausea and anti-emetic use wh...Continue Reading

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Citations

Sep 9, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Imad T Awad, Frances Chung
Feb 13, 2008·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Tayfun AdanirAtilla Sencan
Dec 22, 2012·British Journal of Anaesthesia·M F ElguetaL I Cortinez
May 14, 2009·Therapeutics and Clinical Risk Management·Neil A Muchatuta, Michael J Paech
Jun 10, 2010·Saudi Journal of Anaesthesia·Ahmed TurkistaniAbdelazeem El-Dawlatly
Jun 10, 2010·Saudi Journal of Anaesthesia·Ben Gibbison, Stephen Michael Kinsella
Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Matthias JacobMarkus Rehm
Aug 29, 2006·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·UNKNOWN American Society of PeriAnesthesia Nurses PONV/PDNV Strategic Work Team
Sep 27, 2016·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Honey CalebrantInger Jansson
Jun 1, 2006·Journal of the American College of Surgeons·Kathrine Holte, Henrik Kehlet
Jun 30, 2012·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Lynne FullertonPaul Cheney
Apr 19, 2016·Journal of Intensive Care·Anders Winther Voldby, Birgitte Brandstrup
Dec 16, 2006·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Darren J CoutureAnn Beldia Smith
Jul 21, 2006·Best Practice & Research. Clinical Anaesthesiology·Birgitte Brandstrup
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
May 22, 2007·Anesthesia and Analgesia·Paul F WhiteUNKNOWN Fast-Track Surgery Study Group
Nov 9, 2007·Current Opinion in Anaesthesiology·Paul F White, Matthew Eng
Sep 25, 2008·Anesthesiology·Daniel ChappellMarkus Rehm
Mar 30, 2019·The Cochrane Database of Systematic Reviews·James K JewerRonald B George
Apr 5, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Leonardo GottinEnrico Polati
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Dec 3, 2011·Critical Care Nurse·Angela Smith Collins

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