PMID: 3755020Mar 1, 1986Paper

Effect of intrathecal and intracarotid administration of ketamine on blood pressure and heart rate in rats

Archives Internationales De Pharmacodynamie Et De Thérapie
K M DhasmanaW Erdmann

Abstract

Intrathecal and intracarotid effects of ketamine were investigated in anaesthetized rats. Ketamine was administered in the subarachnoid space in doses ranging from 300 to 1500 micrograms X kg-1. In these doses ketamine produced a short-lasting hypotension and bradycardia which may be due to inhibition of sympathetic outflow from thoraco-lumbar region. On the other hand when ketamine (5 mg X kg-1) was injected into the cerebral circulation it produced a rise in blood pressure and heart rate, probably through a cholinergic mechanism.

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