Abstract
The effect of intravenous amiodarone on spatial and transmural dispersion of ventricular repolarization in patients receiving cardiac resynchronization therapy (CRT) remains unclear. We studied 14 patients with nonischemic heart failure who received CRT with a defibrillator, experienced electrical storm and were treated with intravenous amiodarone. Each patient underwent 12-lead electrocardiography (ECG) and 187-channel repolarization interval-difference mapping electrocardiography (187-ch RIDM-ECG) before and during the intravenous administration of amiodarone infusion. A recurrence of ventricular tachyarrhythmia was observed in 2 patients during the early period of intravenous amiodarone therapy. Intravenous amiodarone increased the corrected QT interval (from 470±52 ms to 508±55 ms, P=0.003), but it significantly decreased the QT dispersion (from 107±35 ms to 49±27 ms, P=0.001), T peak-T end (Tp-e) dispersion (from 86±17 ms to 28±28 ms, P=0.001), and maximum inter-lead difference between corrected Tp-e intervals as measured by using the 187-ch RIDM-ECG (from 83±13 ms to 50±19 ms, P=0.001). Intravenous amiodarone suppressed the electrical storm and decreased the QT and Tp-e dispersions in patients treated by using CRT with a ...Continue Reading
References
Mar 15, 1997·Journal of the American College of Cardiology·S BehrensM R Franz
Aug 15, 1997·Annals of Internal Medicine·A D DesaiR J Sung
Nov 24, 1999·The American Journal of Cardiology·I KodamaJ Toyama
Nov 14, 2000·The American Journal of Cardiology·O GurevitzM Glikson
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Yuanna ChengIgor R Efimov
Dec 20, 2005·Journal of the American College of Cardiology·Jeffrey M FishCharles Antzelevitch
Feb 9, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Serkan TopalogluSule Korkmaz
Jun 15, 2007·JAMA : the Journal of the American Medical Association·Finlay A McAlisterBrian H Rowe
Nov 17, 2007·Cardiovascular Research·Lin WuLuiz Belardinelli
Dec 28, 2007·International Heart Journal·Kenji NakaiHiroshi Kasanuki
Jan 4, 2008·Journal of Cardiovascular Pharmacology and Therapeutics·Sandra MoroSerge Sicouri
Mar 28, 2008·Journal of Cardiovascular Electrophysiology·Hemal M NayakFrancis E Marchlinski
May 14, 2008·International Heart Journal·Kenji NakaiHiroshi Kawata
Dec 9, 2008·American Heart Journal·Maurizio GaspariniUNKNOWN InSync ICD Italian Registry Investigators
Aug 20, 2010·Journal of Electrocardiology·Atsushi SuzukiNobuhisa Hagiwara
Nov 6, 2010·Heart and Vessels·Tsuyoshi ShigaHiroshi Kasanuki
Nov 20, 2012·Current Opinion in Cardiology·Dongsheng Gao, John L Sapp