Effect of intravenous esmolol on analgesic requirements in laparoscopic cholecystectomy

Journal of Anaesthesiology, Clinical Pharmacology
Ritima DhirRipul Oberoi

Abstract

Perioperative beta blockers are also being advocated for modulation of acute pain and reduction of intraoperative anesthetic requirements. This study evaluated the effect of perioperative use of esmolol, an ultra short acting beta blocker, on anesthesia and modulation of post operative pain in patients of laproscopic cholecystectomy. Sixty adult ASA I & II grade patients of either sex, scheduled for laparoscopic cholecystectomy under general anesthesia, were enrolled in the study. The patients were randomly allocated to one of the two groups E or C according to computer generated numbers. Group E- Patients who received loading dose of injection esmolol 0.5 mg/kg in 30 ml isotonic saline, before induction of anesthesia, followed by an IV infusion of esmolol 0.05 μg/kg/min till the completion of surgery and Group C- Patients who received 30 ml of isotonic saline as loading dose and continuous infusion of isotonic saline at the same rate as the esmolol group till the completion of surgery. The baseline MAP at 0 minute was almost similar in both the groups. At 8th minute (time of intubation), MAP increased significantly in group C as compared to group E and remained higher than group E till the end of procedure. Intraoperatively, 1...Continue Reading

References

Oct 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D R MillerJ Hill
May 1, 1985·Pharmacology, Biochemistry, and Behavior·T L Yaksh
Feb 24, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E M DavidsonJ E Chelly
Aug 29, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Homer Yang, Ashraf Fayad
Nov 25, 2003·Anesthesia and Analgesia·Paul F WhiteAlexander Sloninsky

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