Effect of intravenous glucose and euglycemic insulin infusions on short-term appetite and food intake

The American Journal of Physiology
I M ChapmanMichael Horowitz

Abstract

To investigate the short-term effects of insulin on feeding, 14 fasting, young adults received 150-min euglycemic intravenous infusions of control (C), low-dose (LD, 0.8 mU.kg-1.min-1), and high-dose (HD, 1.6 mU.kg-1.min-1) insulin and ate freely from a buffet meal during the last 30 min. Steady-state preprandial plasma insulin concentrations were 5.9 +/- 0.7 (C), 47 +/- 2 (LD), and 95 +/- 6 (HD) microU/ml and increased 56-59 microU/ml during the meal. No effect of treatment type of hunger or fullness ratings, duration of eating, or the weight, energy content (1,053 +/- 95 kcal, C; 1,045 +/- 101 kcal, LD; 1,066 +/- 107 kcal, HD; P = 0.9), and composition of food eaten was observed. On a fourth study day, 12 of the subjects received an intravenous infusion of glucose only (Glc) that was identical to the glucose infusion on their HD insulin day. Mean venous glucose concentration was 9.3 +/- 0.5 mmol [P < 0.001 vs. C (5.3 +/- 0.1), LD (5.2 +/- 0.2), and HD (5.2 +/- 0.2)], and plasma insulin increased to 45 +/- 2.3 microU/ml at the start and 242 +/- 36 microU/ml at the end of the meal. Energy intake during the meal was (approximately 15%) reduced (1,072 +/- 97 kcal, C; 1,086 +/- 102 kcal, LD; 1,088 +/- 105 kcal, HD; 919 +/- 115 kca...Continue Reading

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Citations

Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C K RaynerM Horowitz
Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K BeckoffK L Jones
Mar 31, 2012·Human Brain Mapping·Nils B KroemerMichael N Smolka
Oct 28, 2010·International Journal of Food Sciences and Nutrition·Viren Ranawana, C Jeya K Henry
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C K RaynerM Horowitz

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