Abstract
The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. To evaluate whether timing of IVIG administration might affect clinical outcomes of neonates with severe enteroviral infections. We retrospectively analyzed 67 neonates with culture-confirmed severe enteroviral infection, defined as hepatitis with coagulopathy and thrombocytopenia. Clinical features, outcomes and the usage of IVIG therapy were collected and analyzed. IVIG administered within 3 days of illness onset was classified as early IVIG therapy. Of the 67 cases, 38 (57%) were male, 27 (40%) were premature, 57 (85%) had disease onset within 7 days of life and all but 2 cases were caused by coxsackievirus B group. Ten infants (15%) had clinically evident myocarditis. 41 infants (61%) received IVIG therapy and 29 were early IVIG therapy. Fifteen infants (22%) eventually died, without IVIG therapy for 7 infants. The deceased had a significantly higher peak serum aspartate aminotransferase (AST) level than the survivors (3539 vs. 866 IU/L, p<0.01). The timing of IVIG therapy was highly correlated with the timing of peak AST level in patients with early IVIG therapy. Multiple logistic regression analysi...Continue Reading
References
Nov 1, 1989·The Journal of Infection·T G WreghittG M Gandy
Dec 1, 1988·Digestive Diseases and Sciences·J J Reichling, M M Kaplan
Nov 1, 1986·Reviews of Infectious Diseases·J F Modlin
Nov 1, 1983·Reviews of Infectious Diseases·M H KaplanR G Harper
May 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M J AbzugH A Rotbart
Feb 1, 1995·The Pediatric Infectious Disease Journal·B A JantauschW J Rodriguez
Sep 1, 1993·Clinical Pediatrics·D ValdussJ Dyke
Jan 1, 1994·Circulation·N A DruckerJ W Newburger
Jun 3, 1997·Circulation·D M McNamaraA M Feldman
Jun 1, 1997·The Journal of Perinatal & Neonatal Nursing·C W Trotter
Jan 19, 1999·The Journal of Infection·S M WangJ R Wang
Feb 24, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·H KimuraK Otsuki
Dec 6, 2001·The Pediatric Infectious Disease Journal·M J Abzug
Mar 22, 2002·Journal of Internal Medicine·A TedeschiF M Massari
Aug 30, 2002·European Journal of Pediatrics·Sofia BauerItzhak Levi
Oct 11, 2003·The Pediatric Infectious Disease Journal·Tzou-Yien LinLuan-Yin Chang
Feb 19, 2004·Paediatric Drugs·Mark J Abzug
Feb 27, 2004·European Journal of Pediatrics·Penelope A BryantNigel Curtis
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Neil Kaplowitz
Dec 31, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Patricia PaveseDidier Barnoud
Mar 3, 2006·The Pediatric Infectious Disease Journal·Alison C RentzCarrie L Byington
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Meng-Hsiu YenTzou-Yien Lin
Dec 29, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christine KortsalioudakiAnil Dhawan
Oct 23, 2008·Immunology and Allergy Clinics of North America·Martha M Eibl
Mar 24, 2009·Seminars in Fetal & Neonatal Medicine·Marc Tebruegge, Nigel Curtis
Citations
Dec 10, 2015·Expert Review of Cardiovascular Therapy·Paul F KantorSteven E Lipshultz
Aug 13, 2015·Viruses·Lonneke van der LindenFrank J M van Kuppeveld
Nov 10, 2015·The Journal of Infection·Yuta AizawaAkihiko Saitoh
May 9, 2016·European Journal of Pediatrics·S C M de CromC C Obihara
Jul 9, 2016·Acta Paediatrica·Raakel LuotoTerho Heikkinen
Jan 31, 2017·Current Opinion in Pediatrics·Stephanie A CastilloJames G Dinulos
Oct 30, 2016·Archives of Disease in Childhood. Education and Practice Edition·Simon B Drysdale, Dominic F Kelly
Dec 5, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Iliana BersaniOlivier Danhaive
Nov 10, 2018·Medicine·Junji AzumaKeiichi Ozono
May 23, 2020·Journal of Cardiovascular Translational Research·Ahmed ElsanhourySophie Van Linthout
Feb 23, 2018·BMC Pediatrics·Pin LiuDongchi Zhao
Sep 5, 2019·Frontiers in Cellular and Infection Microbiology·Javier Orlando Cifuente, Gonzalo Moratorio
Jul 20, 2019·Scientific Reports·Chun-Yu YenKeh-Gong Wu
Oct 14, 2020·Nature Reviews. Cardiology·Carsten TschöpeSophie Van Linthout
Feb 2, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ryohei IzumitaAkihiko Saitoh
Nov 8, 2020·Antibodies·Mahdi Alsaleem
Mar 17, 2021·BMC Pediatrics·Meng ZhangDezhi Mu
Apr 1, 2021·Journal of Neurovirology·Fatemeh Farshadpour, Reza Taherkhani
Jun 24, 2016·Microbiology Spectrum·James J Dunn
Jul 6, 2021·Frontiers in Medicine·Shilu MathewHadi M Yassine
Jul 17, 2020·Infectious Disorders Drug Targets·Mahmoud Ahmed EbadaAhmed Wadaa Allah