Effect of intravenous immunoglobulin treatment on brain interferon-gamma and interleukin-6 levels in a rat kindling model

Epilepsy Research
Xiangyang LuoLiyang Liang

Abstract

Many studies indicate that intravenous immunoglobulin (IgG) therapy may decrease symptoms of epilepsy. In this study, we assessed the effects of intravenous IgG in an experimental rat kindling model and attempted to elucidate the underlying mechanism of the IgG effect. For induction of kindling, Wistar rats received repeated intraperitoneal injections of picrotoxin. The serum level of neuron-specific enolase (NSE) was measured to determine seizure severity. Interferon (IFN)-gamma and interleukin (IL)-6 levels were measured in rat hippocampus homogenates. The serum NSE level and hippocampal IFN-gamma level were significantly higher in fully kindled, untreated rats compared to unkindled control rats, whereas IL-6 levels were similar in all groups. Intravenous IgG-treated kindled rats showed NSE and IFN-gamma levels similar to those of control rats, along with lower seizure severity and longer seizure latent period than fully kindled, untreated rats. These results indicate that intravenous immunoglobulin exerts a protective effect on the neurons of kindled rats, potentially by downregulating cytokines in the brain. These results shed light on the mechanism by which intravenous immunoglobulin decreases the severity of epileptic sei...Continue Reading

References

May 1, 1982·The Journal of Pathology·J A RoydsW R Timperley
Dec 1, 1994·Epilepsy Research·B G van EngelenH Meinardi
Jun 1, 1995·Psychiatry and Clinical Neurosciences·H ShiiharaM Ariizumi
Feb 20, 2003·Brain Research. Molecular Brain Research·K A LehtimäkiJ Honkaniemi
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Giovambattista De SarroAngela De Sarro
May 6, 2004·Journal of Neuroscience Methods·R E HulseR P Kraig
Oct 7, 2004·Brain Research Bulletin·Jean Pierre OsesJoão José Freitas Sarkis
Dec 17, 2005·Paediatric Drugs·Mohamad A Mikati, Alhan N Shamseddine

❮ Previous
Next ❯

Citations

Jun 19, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gustavo SilveiraAntonio Lucio Teixeira
Jul 15, 2015·Toxicon : Official Journal of the International Society on Toxinology·Renan Volner RodriguezAna Leonor Abrahão Nencioni
Apr 18, 2015·Pediatric Neurology·Luis E Bello-EspinosaJeffrey Buchhalter
Aug 31, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Madeleine Sharp, Manouchehr Javidan
Sep 7, 2016·Acta Neurologica Scandinavica·F GaoY-J Li
Apr 21, 2020·Current Neuropharmacology·Yam Nath PaudelMohd Farooq Shaikh
Jan 12, 2022·Molecular Neurobiology·Alireza Soltani KhaboushanNima Rezaei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.