Effect of intravenous magnesium sulfate on mortality in patients with severe acute asthma

Respirology : Official Journal of the Asian Pacific Society of Respirology
Junko HirashimaHideo Yasunaga

Abstract

Intravenous magnesium sulfate is used as adjunctive therapy for severe asthma exacerbations. However, previous randomized controlled trials of the administration of intravenous magnesium sulfate for asthma exacerbations have shown mixed results, and no study has evaluated its effect on mortality in patients with life-threatening asthma. The objective of this study was to investigate the association between intravenous magnesium sulfate administration and mortality in patients with severe asthma. Patients with severe asthma requiring intravenous corticosteroids and oxygenation were selected using the Japanese Diagnosis Procedure Combination inpatient database. One-to-one propensity score matching was performed between patients having received or not intravenous magnesium sulfate. Primary outcomes were 7-, 14- and 28-day mortalities. Secondary outcomes were total dose of intravenous corticosteroids during hospitalization, duration of mechanical ventilation and length of stay. Among 14,122 eligible patients, 619 received intravenous magnesium sulfate. Propensity score matching created a matched cohort of 599 pairs with and without intravenous magnesium sulfate. There were no significant differences between patients with and withou...Continue Reading

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Citations

Feb 20, 2019·NPJ Primary Care Respiratory Medicine·Faisal AbuabatMazen Saleh Ferwana
Mar 31, 2020·The American Journal of Emergency Medicine·Brit LongMichael Gottlieb

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