PMID: 8958195Nov 1, 1996Paper

Effect of intravenous magnesium sulfate on cardiac arrhythmias in critically ill patients with low serum ionized magnesium

Japanese Circulation Journal
S KasaokaT Maekawa

Abstract

Magnesium affects cardiac function, although until the recent development of a new ion-selective electrode no method existed for measuring the physiologically active form of magnesium, free ions (iMg2+), in the blood. We investigated the antiarrhythmic effect of magnesium sulfate administered to critically ill patients with cardiac arrhythmias and reduced iMg2+ as determined using the ion-selective electrode. Eight patients with a low iMg2+ level (less than 0.40 mmol/L) were given intravenous magnesium sulfate (group L). Magnesium sulfate was also administered to patients with a normal iMg2+ level (more than 0.40 mmol/L) but who did not respond to conventional antiarrhythmic drugs (group N). Intravenous magnesium sulfate significantly increased the iMg2+ level in patients in group L from 0.35 +/- 0.06 mmol/L (mean +/- SD) to 0.54 +/- 0.09 mmol/L (p < 0.01), and had an antiarrhythmic effect in 7 of the 8 patients (88%). However, in group N patients, intravenous magnesium sulfate had an antiarrhythmic effect in only 1 of the 6 patients (17%) (p < 0.05 vs group L). These results suggest that intravenous magnesium sulfate may be effective in the acute management of cardiac arrhythmias in patients with a low serum iMg2+ level.

References

Jun 1, 1975·The American Journal of Medicine·L T IseriA R Bures
Mar 15, 1989·Biochemical Pharmacology·R E White, H C Hartzell
May 1, 1989·The American Journal of Cardiology·R C WesleyR S Crampton
Nov 15, 1989·The American Journal of Cardiology·B J AllenL T Iseri
Feb 1, 1988·Circulation·D TzivoniS Stern
Oct 1, 1985·American Heart Journal·L T IseriM A Brodsky
Jan 1, 1980·Acta Medica Scandinavica·T Dyckner
Dec 1, 1994·Annals of Emergency Medicine·C M Heesch, E J Eichhorn
Jul 1, 1994·Annals of Emergency Medicine·J V HaysB J Rubal

❮ Previous
Next ❯

Citations

Sep 5, 2015·Journal of Critical Care·Jessica FairleyRinaldo Bellomo
Dec 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D DeheinzelinC Hoelz
Jan 25, 2005·Journal of Intensive Care Medicine·Garrison M Tong, Robert K Rude
Apr 4, 2018·Journal of Intensive Care·Bent-Are Hansen, Øyvind Bruserud
Jun 1, 2018·International Journal of Endocrinology·Abdullah M Al AlawiHenrik Falhammar
Jun 18, 2010·Progress in Biophysics and Molecular Biology·Hiroyuki MatsudaAkinori Noma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Related Papers

International Urology and Nephrology
Carlos G Musso
Pediatrics International : Official Journal of the Japan Pediatric Society
K HoshinoYoshikatsu Etoh
Biochimica Et Biophysica Acta
Feliksas F Bukauskas, Vytas K Verselis
© 2021 Meta ULC. All rights reserved