Effect of intravenous magnesium sulphate on airway calibre and airway reactivity to histamine in asthmatic subjects

British Journal of Clinical Pharmacology
J M Hill, J Britton

Abstract

In a randomized, double-blind, placebo controlled cross-over study we have investigated the effect of intravenous magnesium on airway calibre and airway reactivity to histamine in 20 subjects with mild to moderate asthma. After baseline measurements of forced expiratory volume in one second (FEV1), subjects received 100 ml normal saline with or without 2 g of magnesium sulphate by infusion over 20 min. Measurements of FEV1 were repeated at 5 min intervals throughout the infusion, and the provocative dose of histamine required to drop the FEV1 by 20% from baseline (PD20FEV1) was determined at 20 min. The area under the curve (AUC) in litre minutes for change from baseline in FEV1 between 0 and 20 min was significantly higher on the magnesium study day (mean difference in AUC (95% CI) 1.71 (0.02-3.4), P = 0.049). The increase in FEV1 from baseline with magnesium relative to saline was maximal at 20 min (mean difference (95% CI) 0.13 (0.02-0.23) l, P = 0.01). Log PD20FEV1 to histamine was not significantly different after magnesium and saline (mean difference in log PD20FEV1 (95% CI) 0.04 (-0.19 to 0.27), P = 0.7). We conclude that intravenous magnesium is a weak bronchodilator but does not alter airway reactivity at this dose in ...Continue Reading

References

Jul 1, 1979·British Journal of Clinical Pharmacology·M Hills, P Armitage
Sep 1, 1989·JAMA : the Journal of the American Medical Association·E M SkobeloffL Greenspon
Feb 1, 1987·The Journal of Allergy and Clinical Immunology·K R Patel
Jan 1, 1985·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·E H BrunnerZ H Haddad
Feb 27, 1987·JAMA : the Journal of the American Medical Association·H OkayamaT Takishima

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Citations

May 18, 2004·Nutrition Journal·Welman A Shrader
Jul 25, 2015·International Journal of Clinical Practice·C ThongprayoonS B Erickson
Jun 12, 2014·Indian Journal of Pediatrics·Hui WangJihong Dai
Sep 2, 2000·Annals of Emergency Medicine·H J AlterW M Hilty
May 3, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Fogarty, J Britton
Dec 19, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Waleed H Albuali

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