Effect of intravenous sodium valproate vs dexamethasone on acute migraine headache: a double blind randomized clinical trial

PloS One
Shahir MazaheriMohammad Mahdi Fazlian

Abstract

Despite the impact of sodium valproate and dexamethasone on migraine headache, the efficacy of the two drugs has not been properly investigated and compared. This trial compared the effect of the two drugs on acute migraine headache. This double blind randomized clinical trial was conducted on patients aged 18 to 65 years with acute migraine headache who referred to the emergency departments of Beasat and Farshchian Hospitals in Hamadan, Iran, from April 2012 to June 2014. Patients were randomly assigned to receive a single-dose of either 400 mg sodium valproate or 16 mg dexamethasone plus 50 ml saline normal solution within 15 min intravenously. The severity of headache in the two groups was evaluated at baseline, 0.5 and 2 hours later using the Visual Analog Scale (VAS) on a scale of 0 to 10. Of 104 patients enrolled, 72 patients remained for analysis. The effect of both sodium valproate and dexamethasone on acute migraine headache was statistically significant at 0.5 and 2 hours post-treatment compared to pre-treatment (P=0.001). The severity of headache based on VAS reduced form 8.20 (7.72, 8.68) before treatment to 5.31 (4.74, 5.89) and 3.66 (2.99, 4.33) at 0.5 and 2 hours after treatment, respectively, in patients receivi...Continue Reading

References

Feb 28, 2002·Annals of Emergency Medicine·David R Vinson
Feb 28, 2008·The Annals of Pharmacotherapy·Lawrence A Frazee, Kimberly C Foraker
Aug 20, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·K GhandehariM A Nahayati
Oct 6, 2009·Neuroscience Letters·Antonio PalermoFilippo Brighina
Oct 23, 2009·The Journal of Emergency Medicine·Frederick W FiesselerNima Majlesi
Feb 23, 2010·Lancet Neurology·Turgay DalkaraMichael A Moskowitz
Feb 6, 2013·The American Journal of Emergency Medicine·Babak BakhshayeshMozaffar Hossieninezhad
Feb 14, 2014·Neurology·Benjamin W FriedmanE John Gallagher
Mar 13, 2014·Frontiers in Physiology·Denis SarrouilheMarc Mesnil

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Citations

Feb 21, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mojtaba KhazaeiSoudeh Ghafouri-Fard
Aug 3, 2020·Acta Neurologica Scandinavica·Fengzhi WangQiu He
Sep 13, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ruxian LiZhongling Zhang
Dec 15, 2019·The Journal of Headache and Pain·Evangelos KouremenosUNKNOWN Hellenic Headache Society
Mar 20, 2020·Current Neurology and Neuroscience Reports·Jennifer Robblee, Kate W Grimsrud
Nov 17, 2021·Psychopharmacology·Olivola MiriamNatascia Brondino

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