PMID: 8588946Nov 1, 1995Paper

Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine

Human & Experimental Toxicology
V SteffenJ Cano

Abstract

1-methyl-4-phenylpyridinium (MPP+) is the bioactivated product of 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridine (MPTP). The neurotoxic action of MPP+ injected intracerebroventricularly (ICV) in the rat has been studied, using dopaminergic systems in the substantia nigra, striatum, olfactory bulb, median eminence and hypophysis. The following results were obtained: (1) Rats with ICV administration of 1 microliter MPP+ solution (62.5 micrograms of MPP+ rat) showed 50% mortality; (2) The ICV administration of MPP+ produced a decrease in dopamine (DA) concentration in different areas of rat CNS studied: striatum (83%), hypophysis (95%) and median eminence (70%). However, olfactory bulb and substantia nigra were not affected; (3) MPP+ by ICV administration produced neurotoxic effect on the dopaminergic system. We also studied the possible protective action of acetyl-L-carnitine (ALC) against the neurotoxic action of MPP+. Rats were intraperitoneally injected daily for 8 days with 100 mg kg-1 of ALC and 3 days from the beginning of the MPP+ treatment; (4) We found that the ALC treatment significantly protected against mortality produced by the ICV injection of MPP+. Rats treated with ALC showed no mortality; (5) We did not find a ...Continue Reading

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Citations

Feb 24, 2016·Neurotoxicology and Teratology·Bonnie L RobinsonJyotshna Kanungo
Nov 16, 2004·Annals of the New York Academy of Sciences·Ashraf VirmaniSyed F Ali
Nov 24, 2011·Biochimica Et Biophysica Acta·Vittorio CalabreseEdward J Calabrese
Jul 6, 2016·Neuroscience and Biobehavioral Reviews·Giselli ScainiJoão Quevedo
Feb 12, 2021·Chemical Research in Toxicology·Leah E LathamFang Liu

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