Effect of iomeprol on rat hippocampal slice synaptic transmission: comparison with other X-ray contrast agents

Investigative Radiology
Viviana FrigeniV Lorusso

Abstract

All contrast agents should be neurologically safe because although some are not indicated for procedures, such as myelography, just the same they may come in contact with nervous tissue during contrast-enhanced imaging. This is because even when they are intravascularly injected, the presence of undiagnosed blood-brain barrier damage may allow them to penetrate the brain barrier. In the present study, we investigated the neurologic safety of iomeprol by studying in vitro its potential effects on the central nervous system (CNS) synaptic transmission. Other widely used x-ray contrast agents were also assessed for comparative purposes. CNS synaptic transmission was evaluated in terms of evoked field potentials recorded from the pyramidal region of rat hippocampal slices. The field potentials were evoked by electrical stimulation of the Schaffer collateral pathway. The effects of the contrast agents were evaluated in terms of number and amplitude of population spikes (PS) and as the maximal slope of the excitatory postsynaptic potentials (EPSP). The contrast agents were tested at final concentrations of 3, 10, and 30 mg(iodine)/mL in iso-osmolal condition with respect to artificial cerebrospinal fluid (CSF). Iomeprol, like ioverso...Continue Reading

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Citations

Jun 30, 2007·Journal of Pharmacological and Toxicological Methods·A EasterC E Pollard
Dec 19, 2009·Journal of Veterinary Emergency and Critical Care·Leona LexmaulovaAlois Necas
Nov 26, 2002·Investigative Radiology·Val M Runge

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