PMID: 15226608Jul 1, 2004Paper

Effect of ionizing irradiation on human esophageal cancer cell lines by cDNA microarray gene expression analysis

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Hideki BoOichi Kawanami

Abstract

To provide new insights into the molecular mechanisms underlying the effect of irradiation on esophageal squamous cell carcinomas (ESCCs), we used a cDNA microarray screening of more than 4,000 genes with known functions to identify genes involved in the early response to ionizing irradiation. Two human ESCC cell lines, one each of well (TE-1) and poorly (TE-2) differentiated phenotypes were screened. Subconfluent cells of each phenotype were treated with single doses of 2.0 Gy or 8.0 Gy irradiations. After a 15 min incubation time-point, the cells were collected and analyzed. Compared with non-irradiated cells, many genes revealed at least 2-fold upregulation or downregulation at both doses in well or poorly differentiated ESCC cells. The common upregulated genes in well and poorly differentiated cell types at both irradiation doses included SCYA5, CYP51, SMARCD2, COX6C, MAPK8, FOS, UBE2M, RPL6, PDGFRL, TRAF2, TNFAIP6, ITGB4, GSTM3, and SP3 and common downregulated genes involved NFIL3, SMARCA2, CAPZA1, MetAP2, CITED2, DAP3, MGAT2, ATRX, CIAO1, and STAT6. Several of these genes were novel and not previously known to be associated with irradiation. Functional annotations of the modulated genes suggested that at the molecular le...Continue Reading

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Citations

Apr 21, 2012·Future Oncology·Runhua LiuLizhong Wang
Jul 15, 2009·General Thoracic and Cardiovascular Surgery·Yutaka ShimadaKazuhiro Tsukada
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Sep 1, 2009·Biochimica Et Biophysica Acta·Bansidhar Datta

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