PMID: 558135Mar 1, 1977Paper

Effect of iron and protein deficiency on the expulsion of Nippostrongylus brasiliensis from the small intestine of the rat

Gut
T D BolinJ D Kelly

Abstract

The relationship between iron deficiency and protein deficiency and infestation of the rat with the nematode Nippostrongylus brasiliensis was investigated. There was a significant delay in the expulsion of N. brasiliensis from the small intestine of both iron deficient and protein deficient animals and those with a combined deficiency of iron and protein. Iron repletion returned the time of worm expulsion to normal and this would appear to be related to iron deficiency per se rather than to anaemia. Antibody initiated damage to worms was normal in the control animals and in animals with nutritional deficiencies. This suggests that the defect in worm expulsion occurs either in the cell-mediated immune system or in one of the other mediators of expulsion. Extrapolation to the human situation has important therapeutic implications in that iron and protein deficiency may play an important role in the perpetuation of helminth infestations. Thus, to be successful antihelminth therapy should be accompanied by iron and protein supplementation.

References

Feb 1, 1975·The American Journal of Clinical Nutrition·C G NeumannM Jacob
Jun 1, 1975·The Journal of Pediatrics·R K Chandra, A K Saraya
Jan 1, 1973·International Archives of Allergy and Applied Immunology·J D KellyR J Love
Dec 1, 1972·The Journal of Pediatrics·R K Chandra
Jan 1, 1973·International Archives of Allergy and Applied Immunology·J K Dineen, J D Kelly

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Citations

Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M Tomkins
Dec 1, 1987·Parasitology·D A Bundy, M H Golden
Dec 1, 1986·Parasitology·A G CumminsA E Davis
Jan 1, 1989·Parasitology·D Wakelin
May 26, 2001·Annual Review of Nutrition·K G Koski, M E Scott
Jun 11, 2005·The British Journal of Nutrition·Jos G M HoudijkIlias Kyriazakis
Sep 6, 2005·Brain, Behavior, and Immunity·Frederick BarreauJean Fioramonti
Jun 22, 1978·Nature·D Wakelin
Jul 22, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A F Slater
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R K Grencis

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