Effect of iron supplementation on cognition in Greek preschoolers

European Journal of Clinical Nutrition
E Metallinos-KatsarasE Pollitt

Abstract

To examine effects of iron supplementation on vigilance, attention and conceptual learning in preschool children in Greece. Randomized Double-Blind Placebo Controlled trial of iron. Randomization stratified by iron status and day care center (DCC). Nine public DCCs in Athens, Greece. In all, 49 3-4-y olds (21 anemic, 28 good iron status) with birth weight not less than 2500 g, currently healthy; benign past medical history, IQ > or =1 s.d. below the age-adjusted mean, serum Pb < or =200 ppb (none exceeded 50 ppb), and height, weight and head circumference for age > or =10th percentile. Anemia defined as: (1) pretreatment Hgb <112 g/l and TS <16% and ferritin <12 microg/L OR (2) Hgb rise of >10 g/l (T2-T0) with iron supplementation. Good iron status was defined as baseline levels of Hgb >120 g/l and either TS >20% or serum ferritin >12 microg/l. The intervention consisted of a 2-month supplementation of 15 mg iron (and MV) vs placebo (MV alone). After iron treatment, the anemic subjects made significantly fewer errors of commission (14% higher specificity, P<0.05), exhibited 8% higher accuracy (P<0.05) and were significantly more efficient (mean difference=1.09, P<0.05) than those given placebo. These effects of iron were not fo...Continue Reading

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Citations

Oct 11, 2008·Journal of Child and Adolescent Psychopharmacology·Jaswinder K GhumanBruno J Anthony
Dec 7, 2011·Annals of Nutrition & Metabolism·Maria HermosoBerthold Koletzko
Aug 19, 2006·Srpski arhiv za celokupno lekarstvo·Dusica StojanovićBratimirka Jelenković
Jan 19, 2012·Nutrients·Catherine Geissler, Mamta Singh
Oct 27, 2007·Developmental Neuroscience·Matthew D McEchronMichael D Paronish
Aug 13, 2010·International Journal of Food Sciences and Nutrition·Adebayo O OgunladeJane Kvalsvig
Dec 7, 2007·Pediatric Neurology·Eric KonofalIsabelle Arnulf
Jan 1, 2014·Journal of Paediatrics and Child Health·Samuel SidrakSusan Woolfenden
Oct 30, 2016·Journal of the Academy of Nutrition and Dietetics·Elizabeth Metallinos-KatsarasElizabeth Siu
Dec 13, 2006·The American Journal of Clinical Nutrition·Lora L IannottiRobert E Black
Jun 4, 2019·Annals of the New York Academy of Sciences·Leila Margaret LarsonElizabeth Leah Prado
Jul 9, 2020·Nutrients·Samantha McCannSophie E Moore
Feb 27, 2008·Food and Nutrition Bulletin·Betsy Lozoff
Dec 8, 2005·The American Journal of Clinical Nutrition·Julie M SchneiderSheri Zidenberg-Cherr
Feb 22, 2007·The Journal of Nutrition·Betsy LozoffMaureen Black

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